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Targeting paraptosis in cancer: opportunities and challenges
Cell death can be classified into two primary categories: accidental cell death and regulated cell death (RCD). Within RCD, there are distinct...
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Strategies for develo** Alzheimer’s disease treatments: application of population pharmacokinetic and pharmacodynamic models
BackgroundAs the number of Alzheimer's disease (AD) patients steadily increases, many pharmaceutical industries and researchers are making efforts...
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Tumor extracellular vesicles mediate anti-PD-L1 therapy resistance by decoying anti-PD-L1
PD-L1 + tumor-derived extracellular vesicles (TEVs) cause systemic immunosuppression and possibly resistance to anti-PD-L1 antibody (αPD-L1) blockade....
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RNA gene profile variation in peripheral blood mononuclear cells from rhesus macaques immunized with Hib conjugate vaccine, Hib capsular polysaccharide and TT carrier protein
BackgroundThe Haemophilus influenzae type b (Hib) conjugate vaccine has been widely used in children to prevent invasive Hib disease because of its...
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Role of miR-155 in inflammatory autoimmune diseases: a comprehensive review
PurposeMiR-155 is a member of the microRNAs (miRNAs) family and regulates gene expression post-transcriptionally by binding to the 3'UTR of target...
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The Role of Immunotherapy in Renal Cell Carcinoma
Immunotherapy has long played an integral role in the treatment of advanced renal cell carcinoma, beginning with interleukin-2 and interferon-α and...
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Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients
PurposeDeficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of immunity, characterized by autoinflammation (recurrent fever),...
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Intranasal immunization of mice with chimera of Salmonella Typhi protein elicits protective intestinal immunity
Development of safe, highly effective and affordable enteric fever vaccines is a global health priority. Live, oral typhoid vaccines induce strong...
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Metastatic Lesions of the Brain and Spine
Brain and spinal metastasesMetastases are common in cancer patients and are associated with significant morbidityMorbidity and mortalityMortality....
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Sex differences in resting-state functional networks in awake rats
Sex-related differences can be found in many brain disorders and psychophysiological traits, highlighting the importance to systematically understand...
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Parkinson’s Disease: Neurochemistry and Pharmacological Treatment
Parkinson’s disease (PD) is an age-related neurodegenerative disorder that is characterized by bradykinesia, muscular rigidity, tremors in the hand,...
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Thrombophilia and Its Markers: A Comprehensive Insight
Thrombophilia is defined as the tendency of forming clots inappropriately. The chances of develo** thrombosis can occur either in infancy or in...
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Pharmacological Considerations for Clinical Trials of Host-Directed Therapies for Tuberculosis
The pharmacokinetics (PK) of a drug is commonly explained as ‘what the body does to the drug’ and is typically described in terms of drug...
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Ability of a selfish B chromosome to evade genome elimination in the jewel wasp, Nasonia vitripennis
B chromosomes are non-essential, extra chromosomes that can exhibit transmission-enhancing behaviors, including meiotic drive, mitotic drive, and...
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The KLF14 Variant is Associated with Type 2 Diabetes and HbA1C Level
The purpose of this study was to scan variants in coding region of Krȕppel like factor14 ( KLF14 ) locus and assess association related to type 2...
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The Immunogenetics of Acne
Acne vulgarisAcne vulgaris results from a complex interaction between environment and genetic factors. While colonization of the pilosebaceous unit...
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Biomarker characterization of clinical subtypes of Parkinson Disease
The biological underpinnings of the PD clusters remain unknown as the existing PD clusters lacks biomarker characterization. We try to identify...
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Short-Term Alterations in Behavior and Astroglial Function After Intracerebroventricular Infusion of Methylglyoxal in Rats
Methylglyoxal (MG) is a by-product of glycolysis. In pathological conditions, particularly diabetes mellitus, this molecule is unbalanced, causing...
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Haploidentical Hematopoietic Cell Transplantation Using Post-transplant Cyclophosphamide for Children with Non-malignant Diseases
Haploidentical hematopoietic cell transplantation (HCT) is a valuable curative option for children with non-malignant diseases. Haploidentical HCT...
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Modulation of osteoblast differentiation and function by the P2X4 receptor
Bone cells are known to express multiple P2 receptor subtypes, and the functional effects of receptor activation have been described for many of...
