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Map** the influence of hydrocarbons mixture on molecular mechanisms, involved in breast and lung neoplasms: in silico toxicogenomic data-mining
BackgroundExposure to chemical mixtures inherent in air pollution, has been shown to be associated with the risk of breast and lung cancers. However,...
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Novel Approaches in Cancer Treatment: Tumor Targeted Therapy
Phytochemicals and their derivatives are of great attention in the treatment of cancer. The use of phytochemicals is recognized being a powerful...
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An emerging generation of endocrine therapies in breast cancer: a clinical perspective
Anti-estrogen therapy is a key component of the treatment of both early and advanced-stage hormone receptor (HR)-positive breast cancer. This review...
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Ambra1 in cancer: implications for clinical oncology
Activating molecule in Beclin-1-regulated autophagy protein 1 (Ambra1) is well known to mediate the autophagy process and promote the formation of...
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Machine learning algorithm predicts fibrosis-related blood diagnosis markers of intervertebral disc degeneration
BackgroundIntervertebral disc cell fibrosis has been established as a contributing factor to intervertebral disc degeneration (IDD). This study aimed...
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Therapeutic Efficacy of Roscovitine Against Cancer
Oxidative stress plays an important role in the pathophysiology of many diseases due to unwanted cell death or undesired cell division. Uncontrolled...
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A Crosstalk Between Dual-Specific Phosphatases and Dual-Specific Protein Kinases Can Be A Potential Therapeutic Target for Anti-cancer Therapy
While protein tyrosine kinases (PTKs) play an initiative role in growth factor-mediated cellular processes, protein tyrosine phosphatases (PTPs)...
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CDK5: an oncogene or an anti-oncogene: location location location
Recent studies have uncovered various physiological functions of CDK5 in many nonneuronal tissues. Upregulation of CDK5 and/or its activator p35 in...
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The golden key to open mystery boxes of SMARCA4-deficient undifferentiated thoracic tumor: focusing immunotherapy, tumor microenvironment and epigenetic regulation
SMARCA4-deficient undifferentiated thoracic tumor is extremely invasive. This tumor with poor prognosis is easily confused with SMARCA4-deficent...
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Post-translational modifications of CDK5 and their biological roles in cancer
Post-translational modifications (PTMs) of Cyclin-dependent kinase 5 (CDK5) have emerged as important regulatory mechanisms that modulate cancer...
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Lipid-Based Nanocarriers in the Treatment of Glioblastoma Multiforme (GBM): Challenges and Opportunities
Glioblastoma multiforme (also known as glioblastoma; GBM) is one of the most malignant types of brain tumors that occurs in the CNS. Treatment...
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Unwinding Helicase MCM Functionality for Diagnosis and Therapeutics of Replication Abnormalities Associated with Cancer: A Review
The minichromosome maintenance (MCM) protein is a component of an active helicase that is essential for the initiation of DNA replication....
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Oxidative Stress–a Double Edged Sword in Cancer
Production of free radicals and reactive oxygen species (ROS) inside the cell causes cellular oxidative stress. Superoxides, hydroxyl radicals,...
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The role of alternative pre-mRNA splicing in cancer progression
Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the...
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FERMT1 contributes to the migration and invasion of nasopharyngeal carcinoma through epithelial–mesenchymal transition and cell cycle arrest
BackgroundFermitin family member 1 (FERMT1) is significantly overexpressed in human cancers and associated with poor prognosis, but its contributions...
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Overcoming BRAF and CDK4/6 inhibitor resistance by inhibiting MAP3K3-dependent protection against YAP lysosomal degradation
Transcriptional programs governed by YAP play key roles in conferring resistance to various molecular-targeted anticancer agents. Strategies aimed at...
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Age-specific oncogenic pathways in head and neck squamous cell carcinoma - are elderly a different subcategory?
BackgroundIn recent clinical practice, an increasing number of elderly patients suffering from head and neck squamous cell carcinoma (HNSCC) of...
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Molecular complexity and gene expression controlling cell turnover during a digestive cycle of carnivorous sponge Lycopodina hypogea
Lycopodina hypogea is a carnivorous sponge that tolerates laboratory husbandry very well. During a digestion cycle, performed without any digestive...
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Targeting CRAF kinase in anti-cancer therapy: progress and opportunities
The RAS/mitogen-activated protein kinase (MAPK) signaling cascade is commonly dysregulated in human malignancies by processes driven by RAS or RAF ...
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Role of APR3 in cancer: apoptosis, autophagy, oxidative stress, and cancer therapy
APR3 ( Apoptosis-related protein 3 ) is a gene that has recently been identified to be associated with apoptosis. The gene is located on human...
