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Efficacy of concurrent chemoradiotherapy with retrograde super selective intra-arterial infusion combined with cetuximab for synchronous multifocal oral squamous cell carcinomas
BackgroundThe incidence of multicentric oral cancer is increasing. However, treatment encounters difficulty if each tumor needs to be treated...
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Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action
Damage to cellular macromolecules and organelles by chemical exposure evokes activation of various stress response pathways. To what extent different...
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Intraperitoneal drug delivery systems releasing cytostatic agents to target gastro-intestinal peritoneal metastases in laboratory animals: a systematic review
For peritoneal metastases (PM), there are few curative treatment options, and they are only available for a select patient group. Recently, new...
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Chemoresistance in Colorectal Malignancies: Molecular Mechanisms and Strategies to Overcome.
Colorectal cancer (CRC) remains the third most common cause of cancer-related deaths in both men and women worldwide. Despite recent advances in...
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Antibody-Functionalized Nanoparticles for Targeted Drug Delivery in Cancer Therapy
Targeted therapies using nanoparticles have been proposed to address some drawbacks of conventional chemotherapy. In the last two decades, surface...
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Role of Copolymers in Lung Cancer
Hydrogels, micelles, dendrimers, simple and functionalized nanoparticles, mesoporous particles, and liposomes have all been used effectively to...
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Integrative approach using network pharmacology, bioinformatics, and experimental methods to explore the mechanism of cantharidin in treating colorectal cancer
Cantharidin, a terpenoid produced by blister beetles, has been used in traditional Chinese medicine to treat various ailments and cancers. However,...
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Enhanced histone H3 acetylation of the PD-L1 promoter via the COP1/c-Jun/HDAC3 axis is required for PD-L1 expression in drug-resistant cancer cells
BackgroundDrug resistance is a major obstacle to treating cancers because it desensitizes cancer cells to chemotherapy. Recently, attention has been...
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Immunostimulatory and anti-tumor metronomic cyclophosphamide regimens assessed in primary orthotopic and metastatic murine breast cancer
The impressive successes of immune checkpoint blockade antibodies to treat various types of cancer are limited to minor subsets of patients....
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Immune Response to SARS-CoV-2 Infections in Children with Secondary Immunodeficiencies
Background and PurposeIt is a matter of research, whether children with immunodeficiencies are able to generate an effective immune response to...
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Evaluation of hepatic CYP3A enzyme activity using endogenous markers in lung cancer patients treated with cisplatin, dexamethasone, and aprepitant
PurposeAprepitant is used with dexamethasone and 5-HT 3 receptor antagonists as an antiemetic treatment for chemotherapy, including cisplatin....
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The FOXO family of transcription factors: key molecular players in gastric cancer
Gastric cancer (GC) is the fifth most frequently diagnosed cancer worldwide and the third leading cause of cancer-related death with an oncological...
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Electrochemotherapy of skin metastases from malignant melanoma: a PRISMA-compliant systematic review
The main treatment of MM metastases are systemic therapies, surgery, limb perfusion, and intralesional talimogene laherparepvec. Electrochemotherapy...
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An integrative approach to cisplatin chronic toxicities in mice reveals importance of organic cation-transporter-dependent protein networks for renoprotection
Cisplatin (CDDP) is one of the most important chemotherapeutic drugs in modern oncology. However, its use is limited by severe toxicities, which...
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Chemoradiation versus surgery for superficial esophageal squamous cell carcinoma after noncurative endoscopic submucosal dissection: comparison of long-term oncologic outcomes
BackgroundEsophagectomy is the standard adjuvant treatment for superficial esophageal squamous cell carcinoma (SESCC) following noncurative...
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Comprehensive screening for drugs that modify radiation-induced immune responses
BackgroundCombination therapy based on radiotherapy and immune checkpoint inhibitors (ICIs) was recently reported as effective for various cancers....
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E-Jet 3D-Printed Scaffolds as Sustained Multi-Drug Delivery Vehicles in Breast Cancer Therapy
PurposeCombination chemotherapy is gradually receiving more attention because of its potential synergistic effect and reduced drug doses in clinical...
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Survival outcomes of esophageal cancer patients with recurrence after curative treatments
BackgroundLittle is known about predictive factors for survival outcomes of esophageal carcinoma (EC) patients who developed recurrence after...
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Tumor Microenvironment and Tumor-Targeted Therapy
Cancer tissue or cancer cells do not exist in isolation, but start life within the microenvironment called tumor microenvironment (TME). The...
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Management of non-metastatic anal cancer in the elderly: ancillary study of the French multicenter prospective cohort FFCD-ANABASE
BackgroundStandard care for non-metastatic squamous cell carcinoma of the anus (SCCA) is chemoradiotherapy, data about elderly patients are scarce.
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