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T-Cell Exhaustion in Cancers
There are different concepts that relate to T-cell hyporesponsivity, such as ignorance, tolerance, anergy, aging, and exhaustion. Among these, T-cell...
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Potential clinical implications of CD4+CD26high T cells for nivolumab treated melanoma patients
BackgroundNivolumab is an anti-PD1 antibody that has dramatically improved metastatic melanoma patients’ outcomes. Nevertheless, many patients are...
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Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4+ T-cell large granular lymphocyte leukemia
CD4+ T-cell large granular lymphocyte leukemia (T-LGLL) is a rare subtype of T-LGLL with unknown etiology. In this study, we molecularly...
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Evaluating the immunologically “cold” tumor microenvironment after treatment with immune checkpoint inhibitors utilizing PET imaging of CD4 + and CD8 + T cells in breast cancer mouse models
BackgroundImmune-positron emission tomography (PET) imaging with tracers that target CD8 and granzyme B has shown promise in predicting the...
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The Role of CD4+ T Cells in the Immunotherapy of Brain Disease by Secreting Different Cytokines
Upon different stimulation, naïve CD4 + T cells differentiate into various subsets of T helper (Th) cells, including Th1, Th2, Th17, and Tregs. They...
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Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic TH1 cell responses in Crohn’s disease
Aberrant CD4 + T cell reactivity against intestinal microorganisms is considered to drive mucosal inflammation in inflammatory bowel diseases. The...
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The mRNA expression and secretion of granzyme B are up-regulated via the histamine H2 receptor in human CD4+ T cells
IntroductionGranzyme B (GZMB), a serine protease with cytotoxic and immunomodulatory functions, shows elevated levels in blood plasma of patients...
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Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4+ T cells specific for the epidermal autoantigen desmoglein 3
Various autoimmune responses increase with age, but the underlying mechanism is not clear. In this study, we used CD4 + T cells expressing a...
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T Cell Immunity: T Cell Receptors and Their Effector Functions
T cells constitute up to 30% of all circulating leukocytes and are a major component of the adaptive immune system. In this chapter, we will describe...
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Coordinated Priming of NKG2D Pathway by IL-15 Enhanced Functional Properties of Cytotoxic CD4+CD28− T Cells Expanded in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder, and numerous aberrations of T cell responses have been reported and were...
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The clinical trajectory of peripheral blood immune cell subsets, T-cell activation, and cytokines in septic patients
Objective and designChanges in the immune status of patients with sepsis may have a major impact on their prognosis. Our research focused on changes...
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Alloantigen-activated (AAA) CD4+ T cells reinvigorate host endogenous T cell immunity to eliminate pre-established tumors in mice
BackgroundCancer vaccines that induce endogenous antitumor immunity represent an ideal strategy to overcome intractable cancers. However, doing this...
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Characteristics of T cell premature senescence in maintenance hemodialysis patients
BackgroundUremia-associated immunodeficiency, mainly characterized by T cell dysfunction, exists in patients on maintenance hemodialysis (MHD) and...
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Chagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells
Chagas disease is a neglected tropical disease in Latin America and an imported emerging disease worldwide. Chronic Chagas disease cardiomyopathy...
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Telomerase deficiency reflects age-associated changes in CD4+ T cells
BackgroundAmongst other systemic changes, aging leads to an immune dysfunction. On the molecular level, a hallmark of aging is telomere shortening....
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The intrarenal landscape of T cell receptor repertoire in clear cell renal cell cancer
BackgroundClear cell renal cell cancer (ccRCC) is accompanied by T-cell infiltration. In this study, we sought to determine the difference in T-cell...
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Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation
The nature of activation signals is essential in determining T cell subset differentiation; however, the features that determine T cell subset...
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S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission
Graft-versus-host disease (GVHD) significantly contributes to patient morbidity and mortality after allogeneic hematopoietic cell transplantation...
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COVID-19 vaccination induces distinct T-cell responses in pediatric solid organ transplant recipients and immunocompetent children
Immune responses to COVID-19 vaccination are attenuated in adult solid organ transplant recipients (SOTRs) and additional vaccine doses are...
