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Nucleic acid-loaded poly(beta-aminoester) nanoparticles for cancer nano-immuno therapeutics: the good, the bad, and the future
Immunotherapy has emerged as a promising approach to cancer treatment, offering improved survival rates and enhanced patients’ quality of life....
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Nutrition and Functions of Amino Acids in Fish
Aquaculture is increasingly important for providing humans with high-quality animal protein to improve growth, development and health. Farm-raised...
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Melatonin improves behavioral parameters and oxidative stress in zebrafish submitted to a leucine-induced MSUD protocol
Maple syrup urine disease (MSUD) is an inherited metabolic disorder caused by a deficiency in branched-chain alpha-ketoacid dehydrogenase complex...
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Plasma metabolic profiles predict future dementia and dementia subtypes: a prospective analysis of 274,160 participants
BackgroundBlood-based biomarkers for dementia are gaining attention due to their non-invasive nature and feasibility in regular healthcare settings....
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Exposure to leucine induces oxidative stress in the brain of zebrafish
Maple Syrup Urine Disease (MSUD) is an autosomal recessive inherited disorder caused by a deficiency in the activity of the branched-chain...
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Disclosing a metabolic signature of cisplatin resistance in MDA-MB-231 triple-negative breast cancer cells by NMR metabolomics
This work compared the metabolic profile of a parental MDA-MB-231 cisplatin-sensitive triple negative breast cancer (TNBC) cell line with that of a...
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The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer
Oncogenic KRAS mutations and inactivation of the APC tumor suppressor co-occur in colorectal cancer (CRC). Despite efforts to target mutant KRAS...
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Biomarkers of Malnutrition in Cirrhosis
Malnutrition is highly prevalent in patients with cirrhosis and is associated with increased morbidity and mortality. As a modifiable risk factor,...
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Biomarkers of Malnutrition in Cirrhosis
Malnutrition is highly prevalent in patients with cirrhosis and is associated with increased morbidity and mortality. As a modifiable risk factor,...
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Metabolic Rewiring in Cancer: Understanding the Complexity of Metabolic Networks
Cancer is characterized by uncontrolled cell growth and survival, which entails the reprogramming of metabolic pathways to generate energy and...
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Amino Acids in Intestinal Physiology and Health
Dietary protein digestion is an efficient process resulting in the absorption of amino acids by epithelial cells, mainly in the jejunum. Some amino...
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Amino Acids and Their Metabolites for Improving Human Exercising Performance
Achieving adequate nutrition for exercising humans is especially important for improving both muscle mass and metabolic health. One of the most...
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The biphasic activity of autophagy and heat shock protein response in peripheral blood mononuclear cells following acute resistance exercise in resistance-trained males
PurposeAutophagy and heat shock protein (HSP) response are proteostatic systems involved in the acute and adaptive responses to exercise. These...
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Amino Acids in Cell Signaling: Regulation and Function
Amino acids are the main building blocks for life. Aside from their roles in composing proteins, functional amino acids and their metabolites play...
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High expression of BCAT1 sensitizes AML cells to PARP inhibitor by suppressing DNA damage response
AbstractPrevious evidence has confirmed that branched-chain aminotransferase-1 ( BCAT1 ), a key enzyme governing branched-chain amino acid (BCAA)...
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Transfer RNA-derived fragment tRF-23-Q99P9P9NDD promotes progression of gastric cancer by targeting ACADSB
Gastric cancer (GC) is one of the most common gastrointestinal tumors. As a newly discovered type of non-coding RNAs, transfer RNA (tRNA)-derived...
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Exploiting Apical Sodium-Dependent Bile Acid Transporter (ASBT)-Mediated Endocytosis with Multi-Functional Deoxycholic Acid Grafted Alginate Amide Nanoparticles as an Oral Insulin Delivery System
ObjectiveOral administration of insulin is a potential candidate for managing diabetes. However, it is obstructed by the gastrointestinal tract...
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Dietary Supplementation Strategies for Improving Training Adaptations, Antioxidant Status and Performance of Volleyball Players: A Systematic Review
PurposeVolleyball demands high physical performance including agility, speed, endurance and muscular strength. As volleyball players explore methods...
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Amino Acids in Swine Nutrition and Production
Amino acids are the building blocks of proteins in animals, including swine. With the development of new analytical methods and biochemical research,...
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Increased Hippocampal Afterdischarge Threshold in Ketogenic Diet is Accompanied by Enhanced Kynurenine Pathway Activity
The efficacy of a ketogenic diet (KD) in controlling seizure has been shown in many experimental and clinical studies, however, its mechanism of...
