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Transporter Systems and Metabolism at the Blood–Brain Barrier and Blood–CSF Barrier
Neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), are a leading cause of...
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Isolation and Cryopreservation of Mononuclear Cells from Peripheral Blood and Bone Marrow of Blood Cancer Patients
Peripheral blood and bone marrow aspirates are routinely obtained from blood cancer patients for diagnostic investigations and provide an accessible...
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Evaluation of commercial kits for isolation and bisulfite conversion of circulating cell-free tumor DNA from blood
BackgroundDNA methylation biomarkers in circulating cell-free DNA (cfDNA) have great clinical potential for cancer management. Most methods for DNA...
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Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution
Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. The pathological hallmark of PD is loss of dopaminergic neurons and...
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Single cell transcriptome analysis identified a unique neutrophil type associated with Alzheimer’s disease
BackgroundNeutrophils play an essential role in Alzheimer’s disease (AD) pathology. However, the extent of their heterogeneity remains poorly...
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The Detection of Exosomal PD-L1 in Peripheral Blood
Peripheral blood is a source for liquid biopsy, which can meet the requirements of pretreatment disease ty** to determine precise targeted therapy...
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Cell type-specific roles of APOE4 in Alzheimer disease
The ɛ4 allele of the apolipoprotein E gene ( APOE ), which translates to the APOE4 isoform, is the strongest genetic risk factor for late-onset...
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Contribution of Red Blood Cells and Platelets to Blood Clot Computed Tomography Imaging and Compressive Mechanical Characteristics
Thrombus computed tomography (CT) imaging characteristics may correspond with thrombus mechanical properties and thus predict thrombectomy success....
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Blood–brain borders: a proposal to address limitations of historical blood–brain barrier terminology
Many neuroscientists use the term Blood–Brain Barrier (BBB) to emphasize restrictiveness, often equating or reducing the notion of BBB properties to...
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Integrated models of blood protein and metabolite enhance the diagnostic accuracy for Non-Small Cell Lung Cancer
BackgroundFor early screening and diagnosis of non-small cell lung cancer (NSCLC), a robust model based on plasma proteomics and metabolomics is...
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Changes in saliva protein profile throughout Rhipicephalus microplus blood feeding
BackgroundWhen feeding on a vertebrate host, ticks secrete saliva, which is a complex mixture of proteins, lipids, and other molecules. Tick saliva...
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The Use of Apheresis in Personalized Cell-Mediated Treatment of Prostate Cancer
Beside a supportive therapy of deficient blood component(s) by transfusions, hemotherapy involves the use of apheresis procedures due to plasma or...
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Peripheral Blood Lymphocyte Subsets and Heterogeneity of B Cell Subsets in Patients of Idiopathic Inflammatory Myositis with Different Myositis-specific Autoantibodies
Idiopathic inflammatory myopathies (IIM) are a group of myopathies that present with muscle weakness and multiple extra-muscular manifestations, in...
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SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier
BackgroundAs a consequence of SARS-CoV-2 infection various neurocognitive and neuropsychiatric symptoms can appear, which may persist for several...
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Acute venous thromboembolism plasma and red blood cell metabolomic profiling reveals potential new early diagnostic biomarkers: observational clinical study
BackgroundVenous thromboembolism (VTE) is a leading cause of cardiovascular mortality. The diagnosis of acute VTE is based on complex imaging exams...
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Impaired response of blood neutrophils to cell-death stimulus differentiates AQP4-IgG-seropositive NMOSD from MOGAD
BackgroundIn neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), neutrophils...
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Differential blood cells associated with parasitism in the wild puffer fish Lagocephalus laevigatus (Tetraodontiformes) of the Campeche Coast, southern Mexico
In aquaculture conditions, severe parasitic infections cause negative impacts on fish health and economic losses. The parasite load has been...
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Early diagnosis of ovarian cancer based on methylation profiles in peripheral blood cell-free DNA: a systematic review
Patients diagnosed with epithelial ovarian cancer (OC) have a 5-year survival rate of 49%. For early-stage disease, the 5-year survival rate is above...
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imply : improving cell-type deconvolution accuracy using personalized reference profilesUsing computational tools, bulk transcriptomics can be deconvoluted to estimate the abundance of constituent cell types. However, existing...
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TGFB1, FOXO1, and COMP Genes Expression in Blood of Patients with Osteoarthritis after SARS-CoV2 Infection
Abstract —Nowadays the possible influence of the coronavirus infection on cartilage degeneration and synovial membrane inflammation during chronic...
