Search
Search Results
-
T-cell phenotype including CD57+ T follicular helper cells in the tumor microenvironment correlate with a poor outcome in follicular lymphoma
T-lymphocytes are prevalent in the tumor microenvironment of follicular lymphoma (FL). However, the phenotype of T-cells may vary, and the prevalence...
-
Physiologically Based Pharmacokinetic (PBPK) Modelling
Since its introduction in 1937 by Teorell, physiologically based pharmacokinetic (PBPK) modelling has come to a point, that apart from becoming an...
-
Commissioning of Aktina SRS cones and dosimetric validation of the RayStation photon Monte Carlo dose calculation algorithm
Clinical implementation of SRS cones demands particular experimental care and dosimetric considerations in order to deliver precise and safe...
-
The decoder design and performance comparative analysis for closed-loop brain–machine interface system
Brain–machine interface (BMI) can convert electroencephalography signals (EEGs) into the control instructions of external devices, and the key of...
-
Meeting Report: Vaccine Stability Considerations to Enable Rapid Development and Deployment
The Stability Community of the American Association of Pharmaceutical Scientists (AAPS) held a virtual workshop on “Vaccine Stability Considerations...
-
Nigella sativa and its chemical constituents: pre-clinical and clinical evidence for their potential anti-SARS-CoV-2 effects
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over 500 million reported cases of COVID-19 worldwide with relatively high...
-
A comprehensive evaluation of microbial differential abundance analysis methods: current status and potential solutions
BackgroundDifferential abundance analysis (DAA) is one central statistical task in microbiome data analysis. A robust and powerful DAA tool can help...
-
Effect of fecal microbiota transplantation in patients with slow transit constipation and the relative mechanisms based on the protein digestion and absorption pathway
BackgroundFecal microbiota transplantation (FMT) is considered an effective treatment for slow transit constipation (STC); nevertheless, the...
-
Symmetry-based representation for registration of multimodal images
We propose a new two-dimensional structural representation method for registration of multimodal images by using the local structural symmetry of...
-
Best Practices and Guidelines (2022) for Scale-Up and Tech Transfer in Freeze-Drying Based on Case Studies. Part 1: Challenges during Scale Up and Transfer
The freeze-drying process scale-up and transfer remain a complicated and non-uniform practice. We summarized inefficient and good practices in these...
-
Solvent-Casted Films to Assist Polymer Selection for Amorphous Solid Dispersions During Preclinical Studies: In-vitro and In-vivo Exploration
PurposeThe use of two solvent-casted film methods to select optimal polymer compositions for amorphous solid dispersions prepared to support...
-
The Role of Health Systems in the Control of Neglected Tropical Diseases in Sub-Saharan Africa
Neglected tropical diseases (NTDs) mostly affect populations with low socio-economic status and limited access to healthcare. The opportunity to...
-
Neuroevolutive Algorithms Applied for Modeling Some Biochemical Separation Processes
Combining artificial neural networks with evolutive/bioinspired approaches is a technique that can solve a variety of issues regarding the topology...
-
De Novo Dissecting the Three-Dimensional Facial Morphology of 2379 Han Chinese Individuals
Phenotypic diversity, especially that of facial morphology, has not been fully investigated in the Han Chinese, which is the largest ethnic group in...
-
TPM, FPKM, or Normalized Counts? A Comparative Study of Quantification Measures for the Analysis of RNA-seq Data from the NCI Patient-Derived Models Repository
BackgroundIn order to correctly decode phenotypic information from RNA-sequencing (RNA-seq) data, careful selection of the RNA-seq quantification...
-
Weighted average ensemble-based semantic segmentation in biological electron microscopy images
Semantic segmentation of electron microscopy images using deep learning methods is a valuable tool for the detailed analysis of organelles and cell...
-
Applications, Challenges, and Outlook for PBPK Modeling and Simulation: A Regulatory, Industrial and Academic Perspective
Several regulatory guidances on the use of physiologically based pharmacokinetic (PBPK) analyses and physiologically based biopharmaceutics model(s)...
-
A deep learning approach to median nerve evaluation in ultrasound images of carpal tunnel inlet
Ultrasound (US) imaging is recognized as a useful support for Carpal Tunnel Syndrome (CTS) assessment through the evaluation of median nerve...
-
Fast and accurate population admixture inference from genotype data from a few microsatellites to millions of SNPs
Model-based (likelihood and Bayesian) and non-model-based (PCA and K -means clustering) methods were developed to identify populations and assign...
-
Application of toxicology in silico methods for prediction of acute toxicity (LD50) for Novichoks
Novichoks represent the fourth generation of chemical warfare agents with paralytic and convulsive effects, produced clandestinely during the Cold...
