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Development of a rapid diagnostic test based on loop-mediated isothermal amplification to identify the most frequent non-typhoidal Salmonella serovars from culture
Identification of Salmonella serovars is performed by conventional seroagglutination or sequencing. These methods are labor-intensive and require...
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Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo
AbstractCytoplasmic aggregation and concomitant nuclear clearance of the RNA-binding protein TDP-43 are found in ~ 90% of cases of amyotrophic...
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Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine
A malaria vaccine that blocks parasite transmission from human to mosquito would be a powerful method of disrupting the parasite lifecycle and...
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The immunology of type 1 diabetes
Following the seminal discovery of insulin a century ago, treatment of individuals with type 1 diabetes (T1D) has been largely restricted to efforts...
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Gadd45 in Preeclampsia
Preeclampsia is a pregnancy-induced complex of multiple pathological changes. Numerous stresses during pregnancy, including hypoxia, immune...
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Increased expression of PD-1 in CD8 + CD3 + T cells correlates with EBV viral load in MS patients
Multiple sclerosis (MS) is one of the common autoimmune diseases. The exact etiology of MS is still unclear, but recent studies have shown the...
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Evolution of cell therapy for renal cell carcinoma
Treatment for renal cell carcinoma (RCC) has improved dramatically over the last decade, shifting from high-dose cytokine therapy in combination with...
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Development of nano-immunotherapy for cancer treatment: achievements and scopes
BackgroundCancer immunotherapy, which activates the immune system of the human body to fight cancer cells, is a new paradigm for cancer treatment...
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Microorganisms in the Pathogenesis and Management of Primary Biliary Cholangitis (with Focus on SARS-CoV-2 & Gut Microbiota)
Primary biliary cholangitis is a chronic cholestatic liver disease characterized by a selective and progressive destruction of interlobular bile...
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Tumor Necrosis Factor-Alpha (TNF-Alpha) as a Biomarker in Trauma and Critical Care
Tumor necrosis factor-alpha (TNF-α) is mainly synthesized from monocytes and macrophages. It is a kind of glycoprotein that also contributes to the...
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Direct and indirect impact of SARS-CoV-2 on the brain
Although COVID-19 is mostly a pulmonary disease, it is now well accepted that it can cause a much broader spectrum of signs and symptoms and affect...
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Immune complexes as culprits of immunopathology in severe COVID-19
Infection with the pandemic human coronavirus SARS-CoV-2 elicits a respiratory tract disease, termed Coronavirus disease 2019 (COVID-19). While a...
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Fever as an evolutionary agent to select immune complexes interfaces
We herein analyzed all available protein–protein interfaces of the immune complexes from the Protein Data Bank whose antigens belong to pathogens or...
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The oldest unvaccinated Covid-19 survivors in South America
BackgroundAlthough older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent...
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A robust deep learning workflow to predict CD8 + T-cell epitopes
BackgroundT-cells play a crucial role in the adaptive immune system by triggering responses against cancer cells and pathogens, while maintaining...
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The Promise of Immunotherapeutics and Vaccines in the Treatment of Cancer
The Cancer Moonshot aspires to cut the death rate from cancer by at least 50% over the next 25 years by 2047 and improve the experience of people and...
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Immune Thrombocytopenic Purpura (ITP) and Chorioretinopathy in Chronic Granulomatous Disease: A Case Report
BackgroundChronic Granulomatous Disease (CGD) is a rare immunodeficiency disorder characterized by impaired phagocytic function, leading to recurrent...
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Peptide aptamer-based time-resolved fluoroimmunoassay for CHIKV diagnosis
BackgroundChikungunya virus (CHIKV) and Dengue virus (DENV) have similar clinical symptoms, which often induce misdiagnoses. Therefore, an antigen...
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A safe and potentiated multi-type HPV L2-E7 nanoparticle vaccine with combined prophylactic and therapeutic activity
Persistent infection with high-risk human papillomavirus (HPV) is widely recognized as the primary cause of cervical and other malignant cancers....
