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Relationship Between Genetic Polymorphisms in Cell Cycle Regulatory Gene TP53 and Polycystic Ovarian Syndrome: A Case–Control Study and In Silico Analyses
Polycystic ovarian syndrome (PCOS) is a complex endocrine and metabolic condition with several potential causes. Insulin resistance is a hallmark of...
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Dissecting cell fate dynamics in pediatric glioblastoma through the lens of complex systems and cellular cybernetics
Cancers are complex dynamic ecosystems. Reductionist approaches to science are inadequate in characterizing their self-organized patterns and...
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Cell Polarity in Drosophila Retina
Apical-basal cell polarity is crucial for the development of multicellular organisms and for the diverse functions of epithelial cells in diverse...
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Molecular Pathways and Animal Models of Defects in Situs
Left–right patterning is among the least well understood of the three axes defining the body plan, and yet it is no less important, with left–right...
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Hepatocyte organoids and cell transplantation: What the future holds
Historically, primary hepatocytes have been difficult to expand or maintain in vitro. In this review, we will focus on recent advances in...
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Metabolic lactate production coordinates vasculature development and progenitor behavior in the develo** mouse neocortex
Proper neural progenitor behavior in conjunction with orderly vasculature formation is fundamental to the development of the neocortex. However, the...
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Indirect neurogenesis in space and time
During central nervous system (CNS) development, neural progenitor cells (NPCs) generate neurons and glia in two different ways. In direct...
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Role of Notch Signalling in Oxidative Stress and Stem Cell Self-Renewal During Colitis and Colon Cancer
Colon cancer is responsible for high mortality rates which makes it a major health problem worldwide. Oxidative stress is associated with colon...
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Disparate progenitor cell populations contribute to maintenance and repair neurogenesis in the zebrafish olfactory epithelium
Olfactory sensory neurons (OSNs) undergo constant turnover under physiological conditions but also regenerate efficiently following tissue injury....
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Rho Kinases in Embryonic Development and Stem Cell Research
The Rho-associated coiled-coil containing kinases (ROCKs or Rho kinases) belong to the AGC (PKA/PKG/PKC) family of serine/threonine kinases and are...
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CD8+ T cell differentiation and dysfunction in cancer
CD8 + T cells specific for cancer cells are detected within tumours. However, despite their presence, tumours progress. The clinical success of immune...
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Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases
The last decade has revealed new roles for Cullin-RING ubiquitin ligases (CRLs) in a myriad of cellular processes, including cell cycle progression....
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Role of Notch Signalling in Oxidative Stress and Stem Cell Self-Renewal During Colitis and Colon Cancer
Colon cancer is responsible for high mortality rates which makes it a major health problem worldwide. Oxidative stress is associated with colon...
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Immune cell-mediated features of non-alcoholic steatohepatitis
Non-alcoholic fatty liver disease (NAFLD) includes a range of hepatic manifestations, starting with liver steatosis and potentially evolving towards...
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Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis
Genes involved in synaptic function are enriched among those with autism spectrum disorder (ASD)-associated rare genetic variants. Dysregulated...
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Progress in Modeling Neural Tube Development and Defects by Organoid Reconstruction
It is clear that organoids are useful for studying the structure as well as the functions of organs and tissues; they are able to simulate...
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Cancer Stem Cells in Cancer Initiation and Progression
Cancer stem cells (CSCs) are a subclass of cancer cells that can differentiate into various cell types and self-renew, similar to normal stem cells....
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Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling
BackgroundOpioid and beta-adrenergic receptors are recently shown to cross talk via formation of receptor heterodimers to control the growth and...
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Mechanisms and cell lineages in lymphatic vascular development
Lymphatic vessels have critical roles in both health and disease and their study is a rapidly evolving area of vascular biology. The consensus on how...
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Decoding Cortical Glial Cell Development
Mouse cortical radial glial cells (RGCs) are primary neural stem cells that give rise to cortical oligodendrocytes, astrocytes, and olfactory bulb...
