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Vagus nerve stimulation in the non-human primate: implantation methodology, characterization of nerve anatomy, target engagement and experimental applications
BackgroundVagus nerve stimulation (VNS) is a FDA approved therapy regularly used to treat a variety of neurological disorders that impact the central...
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Ventromedial prefrontal cortex CRF1 receptors modulate the tachycardic activity of baroreflex
Ventral medial prefrontal cortex (vMPFC) glutamatergic neurotransmission has a facilitatory role on cardiac baroreflex activity which is mediated by...
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Seasonal variation of right heart function in elite skiers-racers: an echocardiographic study
PurposeTo examine seasonal variation of the right heart (RH) structure and function in elite skiers-racers.
MethodsThe same group of 16 male was...
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Effect of coronary artery bypass grafting on blood pressure response to head-up tilting
Blood pressure response to head-up tilt (HUT) in 7 healthy subjects and 9 patients before and after coronary artery bypass grafting (CABG) was...
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Acute hypotension attenuates brachial flow-mediated dilation in young healthy men
PurposeThis study aimed to test our hypothesis that acute hypotension attenuates brachial flow-mediated dilation (FMD) as an index of endothelial...
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The effect of hypercapnia on regional cerebral blood flow regulation during progressive lower-body negative pressure
PurposePrevious work indicates that dynamic cerebral blood flow (CBF) regulation is impaired during hypercapnia; however, less is known about the...
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Sex differences in baroreflex function in health and disease
This brief review summarizes the current knowledge on sex differences in baroreflex function, with a major focus on studies in humans. It has been...
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Relationship Between Cerebral Oxygenation and Skin Blood Flow at the Frontal Lobe during Progressive Hypoxia: Impact of Acute Hypotension
We investigated the relationship between cerebral oxygenation (COX) and skin blood flow (SkBF) at the left frontal lobes of 10 healthy young men...
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Vascular smooth muscle-specific LRRC8A knockout ameliorates angiotensin II-induced cerebrovascular remodeling by inhibiting the WNK1/FOXO3a/MMP signaling pathway
Hypertensive cerebrovascular remodeling involves the enlargement of vascular smooth muscle cells (VSMCs), which activates volume-regulated Cl − ...
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Interleukin-1β in hypothalamic paraventricular nucleus mediates excitatory renal reflex
Chemical stimulation of kidney causes sympathetic activation and pressor responses in rats. The excitatory renal reflex (ERR) is mediated by...
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Biomarkers of Sepsis and a Focus on PCSK9
Sepsis is a time-dependent disease and a prompt diagnosis and treatment may improve the outcome. In the actuality, we do not have a reliable...
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Effects of a highly intensive clean and jerk exercise on blood pressure and arterial stiffness in experienced non-professional weight lifters
PurposeWeight lifting training has gained much popularity in recent years and is frequently used in non-professional and professional settings....
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Perivascular Innervation of the Pulmonary Artery in Human and Swine: A Comparative Study for the Development of an Experimental Model of Denervation
For studying the possibility of using catheter denervation of the pulmonary artery for the treatment of pulmonary hypertension, large animals, such...
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Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans
The mechanisms by which physical exercise benefits brain functions are not fully understood. Here, we show that vertically oscillating head motions...
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Heat adaptation in humans: the significance of controlled and regulated variables for experimental design and interpretation
Herein, the principles of homoeostasis are re-visited, but with an emphasis upon repeated homoeostatic disturbances that give rise to physiological...
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Characterization of heart rate changes associated with autonomic dysreflexia during penile vibrostimulation and urodynamics
Study designSecondary data analysis.
ObjectivesTo characterize autonomic dysreflexia (AD) associated heart rate (HR) changes during penile...
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Muscle sympathetic nerve activity during exercise
Appropriate cardiovascular adjustment is necessary to meet the metabolic demands of working skeletal muscle during exercise. The sympathetic nervous...
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Physiology of Cardiovascular System
Maintenance of adequate perfusion to the tissues is achieved by circulation of limited volume blood driven by the intermittently contracting heart...
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Neurophysiology and Renal System
Central nervous system and renal system – two of the most vital organ systems of our body are both structurally and functionally inter-linked. This...
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