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Kinetics of glucose-6-phosphate dehydrogenase (G6PD) activity during Plasmodium vivax infection: implications for early radical malaria treatment
BackgroundPlasmodium vivax relapses due to dormant liver hypnozoites can be prevented with primaquine. However, the dose must be adjusted in...
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Molecular surveillance for operationally relevant genetic polymorphisms in Plasmodium falciparum in Southern Chad, 2016–2017
BackgroundResistance to anti-malarials is a serious threat to the efforts to control and eliminate malaria. Surveillance based on simple field...
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Time to scale up molecular surveillance for anti-malarial drug resistance in sub-saharan Africa
Artemisinin resistance has emerged and spread in the Greater Mekong Sub-region (GMS), followed by artemisinin-based combination therapy failure, due...
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Ferroptotic therapy in cancer: benefits, side effects, and risks
Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane...
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The effect of an anti-malarial herbal remedy, Maytenus senegalensis, on electrocardiograms of healthy Tanzanian volunteers
BackgroundThe emergence of resistance to artemisinin-based combination therapy necessitates the search for new, more potent antiplasmodial compounds,...
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Therapeutic efficacy and tolerability of artemether–lumefantrine for uncomplicated Plasmodium falciparum malaria in Niger, 2020
BackgroundMonitoring therapeutic efficacy is important to ensure the efficacy of artemisinin-based combination therapy (ACT) for malaria. The current...
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Prescription patterns and compliance with World Health Organization recommendations for the management of uncomplicated and severe malaria: A prospective, real-world study in sub-Saharan Africa
BackgroundThis study aimed to evaluate the gap between guidelines and local clinical practice for diagnosis and treatment of uncomplicated and severe...
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Effectiveness of artemether–lumefantrine for treating uncomplicated malaria in low- and high-transmission areas of Ghana
BackgroundArtemisinin-based combination therapy (ACT) has been effective in the supervised treatment of uncomplicated malaria in Ghana. Since ACT...
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Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study
BackgroundThe World Health Organization (WHO) recommendation of treating uncomplicated malaria during the second and third trimester of pregnancy...
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The return of chloroquine-sensitive Plasmodium falciparum parasites in Jazan region, southwestern Saudi Arabia over a decade after the adoption of artemisinin-based combination therapy: analysis of genetic mutations in the pfcrt gene
This study investigated the polymorphism in the P. falciparum chloroquine resistance transporter ( pfcrt ) gene 11 years after chloroquine (CQ)...
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Curcumin potentiates the anti-inflammatory effects of Tehranolide by modulating the STAT3/NF-κB signaling pathway in breast and ovarian cancer cell lines
BackgroundStudies have demonstrated that natural products, such as curcumin and artemisinin, possess anti-inflammatory effects, which can be...
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How has mass drug administration with dihydroartemisinin-piperaquine impacted molecular markers of drug resistance? A systematic review
The World Health Organization (WHO) recommends surveillance of molecular markers of resistance to anti-malarial drugs. This is particularly important...
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Induction and application of ferroptosis in cancer therapy
At present, more than one cell death pathways have been found, one of which is ferroptosis. Ferroptosis was discovered in 2012 and described as an...
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Rebound of multiple infections and prevalence of anti-malarial resistance associated markers following malaria upsurges in Dielmo village, Senegal, West Africa
BackgroundThanks to the scale up of malaria control interventions, the malaria burden in Senegal has decreased substantially to the point that the...
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Anti-malarial resistance in Mozambique: Absence of Plasmodium falciparum Kelch 13 (K13) propeller domain polymorphisms associated with resistance to artemisinins
BackgroundMalaria remains one of the most serious public health problems in sub-Saharan Africa and Mozambique is the world's fourth largest...
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Molecular surveillance of Kelch 13 polymorphisms in Plasmodium falciparum isolates from Kenya and Ethiopia
BackgroundTimely molecular surveillance of Plasmodium falciparum kelch 13 ( k13 ) gene mutations is essential for monitoring the emergence and...
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Natural Immunomodulatory Agents as a Complementary Therapy for Poxviruses
PoxvirusesPoxviruses target innate immunity mediators such as tumor necrosis factors, interleukins, interferons, complement, and chemokines. It also...
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Progress towards malaria elimination in the Greater Mekong Subregion: perspectives from the World Health Organization
Malaria remains a global health challenge, disproportionately affecting vulnerable communities. Despite substantial progress, the emergence of...
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Stakeholder perceptions on the deployment of multiple first-line therapies for uncomplicated malaria: a qualitative study in the health district of Kaya, Burkina Faso
BackgroundIn Burkina Faso, malaria remains the first cause of medical consultation and hospitalization in health centres. First-line case management...
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Synergistic effect of combination chemotherapy with praziquantel and DW-3-15 for Schistosoma japonicum in vitro and in vivo
BackgroundSchistosomiasis is a debilitating and neglected tropical disease for which praziquantel (PZQ) remains the first-choice drug for treatment...
