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Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome
BackgroundInborn errors of immunity (IEI) and autoantibodies to type I interferons (IFNs) underlie critical COVID-19 pneumonia in at least 15% of the...
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Recombinant IFN-γ1b Treatment in a Patient with Inherited IFN-γ Deficiency
PurposeInborn errors of IFN-γ immunity underlie Mendelian susceptibility to mycobacterial disease (MSMD). Twenty-two genes with products involved in...
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Citicoline and COVID-19: vis-à-vis conjectured
Coronavirus disease 2019 (COVID-19) is a current pandemic disease caused by a novel severe acute respiratory syndrome coronavirus virus respiratory...
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Microorganisms in the Pathogenesis and Management of Immune Thrombocytopenia (ITP)
Immune thrombocytopenia (ITP) represents an immune-mediated condition characterized by isolated thrombocytopenia due to the production of...
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Release of Antibodies and Cytokines from B Cells
Autoreactive B cells play a critical role in rheumatoid arthritis (RA). These cells differentiate into long-living memory B cells and...
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Myasthenia Gravis
Autoimmune diseases are becoming increasingly important with respect to the quality of life and health in modern societies. Myasthenia gravis (MG) is...
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Novel Insights into the Autoimmunity from the Genetic Approach of the Human Disease
Autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a monogenic inborn error of autoimmunity that is caused by damaging...
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Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases
BackgroundAutoantibodies against myelin oligodendrocyte glycoprotein (anti-MOG-Abs) occur in a majority of children with acquired demyelinating...
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Bruton’s tyrosine kinase-bearing B cells and microglia in neuromyelitis optica spectrum disorder
BackgroundNeuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disease of the central nervous system that involves B-cell...
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Multi-proteomic Analysis Revealed Distinct Protein Profiles in Cerebrospinal Fluid of Patients Between Anti-NMDAR Encephalitis NORSE and Cryptogenic NORSE
New-onset refractory status epilepticus (NORSE) is rare but intractable. Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis and cryptogenic...
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Breaking tolerance: the autoimmune aspect of atherosclerosis
Atherosclerotic cardiovascular disease (ASCVD) is a chronic inflammatory disease of the arterial walls and is characterized by the accumulation of...
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Role of the innate and adaptive immune responses in the pathogenesis of systemic lupus erythematosus
ObjectiveSystemic lupus erythematosus (SLE), the most common form of lupus, is a multisystemic rheumatic disease with different clinical features...
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The oldest unvaccinated Covid-19 survivors in South America
BackgroundAlthough older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent...
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Cholinergic dysfunction in COVID-19: frantic search and ho** for the best
A novel coronavirus known as severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a potential cause of acute respiratory infection...
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Antibody against apolipoprotein-A1, non-alcoholic fatty liver disease and cardiovascular risk: a translational study
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a common liver disease increasing cardiovascular disease (CVD) morbidity and mortality....
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Clinical Trials and Outcomes in Anti-inflammatory Therapies
Inflammatory diseases represent a diverse group of disorders stemming from an overactive immune response, affecting various organs and tissues and...
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Microorganisms in Pathogenesis and Management of Autoimmune Hepatitis (AIH)
Autoimmune hepatitis (AIH) is the inflammation of the liver that occurs when your body’s immune system turns against liver cells. AIH is more...
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Immunotherapy for Autoimmune Diseases
Various pathologies caused by a dysregulated immune system characterized by chronic inflammation leading to pain or permanent damage to tissue are...
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Microorganisms in Pathogenesis and Management of Graves’ Disease
Graves’ disease (GD) is an organ-specific autoimmune disorder associated with serum antithyroid-stimulating hormone receptor autoantibodies, and it...
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SHP2: its association and roles in systemic lupus erythematosus
ObjectiveSystemic lupus erythematosus (SLE) is an autoimmune inflammatory disease. Src homology 2 domain containing protein tyrosine phosphatase...
