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Role of Probiotics and Synbiotics in Mitigating Alcohol-Induced Liver Damage
Globally, alcohol-induced liver damage is an important issue and is pathologically manifested as fatty liver, alcoholic hepatitis, alcoholic...
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The catechol-O-methyltransferase inhibitor tolcapone modulates alcohol consumption and impulsive choice in alcohol use disorder
RationaleIndividuals suffering from alcohol use disorder (AUD) demonstrate difficulty with decision-making and impulsivity that may be associated...
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Gallstone disease, diabetes, calcium, triglycerides, smoking and alcohol consumption and pancreatitis risk: Mendelian randomization study
We conducted a Mendelian randomization study to determine the potential causal associations of gallstone disease, diabetes, serum calcium,...
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Features of Decision-Making in Patients with Alcohol Dependence
Objectives . To identify electroencephalographic correlates of decision-making features in patients with alcohol dependence. Materials and methods ....
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Alcohol Use Screening in Pregnant and Childbearing Aged Women: Practices and Implications
Global trends demonstrate increasing alcohol consumption among women of childbearing age, social acceptability of women’s alcohol use, as well as...
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Coffee consumption and periodontitis: a Mendelian Randomization study
BackgroundCoffee is one of the most consumed beverages in the world, coffee consumption has been growing in the United States over the past 20 years....
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Genetics and epigenetics: paternal adolescent ethanol consumption in serotonin transporter knock-out rats and offspring sensitivity to ethanol
RationaleAlcohol use disorder (AUD) is shown to have an overall heritability of around 50%. One of the genes associated with AUD is SLC6A4 (solute...
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The neutral CB1 antagonist AM6527 reduces ethanol seeking, binge-like consumption, reinforcing, and withdrawal effects in male and female mice
RationaleAlcohol use disorder (AUD) is a debilitating physiological and psychiatric disorder which affects individuals globally. The current...
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Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae
RationaleEmerging evidence indicates that persistent alcohol consumption escalates psychosocial trauma achieved by social defeat stress (SDS)-induced...
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Sex-dependent divergence in the effects of GLP-1 agonist exendin-4 on alcohol reinforcement and reinstatement in C57BL/6J mice
RationaleAlcohol use disorder remains a leading cause of preventable deaths, and current treatments have limited efficacy. Glucagon-like peptide 1...
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NLRP3 deficiency decreases alcohol intake controlling anxiety-like behavior via modification of glutamatergic transmission in corticostriatal circuits
BackgroundAlcohol use disorders result from repeated binge and chronic alcohol consumption followed by negative effects, such as anxiety, upon...
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How much do Europeans know about the link between alcohol use and cancer? Results from an online survey in 14 countries
ObjectiveIn the EU, which has the highest drinking levels worldwide, cancer is the primary cause of alcohol-attributable deaths. Existing studies...
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Effects of alcohol and task difficulty on visual tracking and inattentional blindness
RationaleInattentional blindness (IB) describes the failure to notice salient but unexpected stimuli in one’s focal visual field. It typically occurs...
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Molecular Mechanism of Beneficial Effects of Probiotics in Alcohol-Induced Liver Disorder
Regular consumption of alcohol remains a predominant cause of a variety of hepatic disorders. There exist many alcohol-induced liver diseases...
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On the interrelation between alcohol addiction–like behaviors in rats
RationaleAlcohol use disorder (AUD) is a complex, heterogeneous disorder that only occurs in a minority of alcohol users. Various behavioral...
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The Blinded-Dose Purchase Task: assessing hypothetical demand based on cocaine, methamphetamine, and alcohol administration
RationaleBehavioral economic drug purchase tasks quantify the reinforcing value of a drug (i.e., demand). Although widely used to assess demand, drug...
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Association of meat consumption with the risk of gastrointestinal cancers: a systematic review and meta-analysis
BackgroundThe association between gastrointestinal cancer and types of meat consumption, including red meat, processed meat, or a combination of...
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Genetics and Family History of Alcohol Use Disorders
Alcohol use disordersAlcohol use disorders (AUD) are complex traits that are moderately heritable. A variety of approaches have been developed that...
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The BDNF Val68Met polymorphism causes a sex specific alcohol preference over social interaction and also acute tolerance to the anxiolytic effects of alcohol, a phenotype driven by malfunction of BDNF in the ventral hippocampus of male mice
BackgroundThe brain-derived neurotrophic factor (BDNF) Valine 66 to Methionine human polymorphism results in impaired activity-dependent BDNF release...
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Alcohol-induced damage to the fimbria/fornix reduces hippocampal-prefrontal cortex connection during early abstinence
IntroductionAlcohol dependence is characterized by a gradual reduction in cognitive control and inflexibility to contingency changes. The...
