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H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFκB signaling pathway
Cellular senescence serves as a fundamental and underlying activity that drives the aging process, and it is intricately associated with numerous...
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Oxidative stress and epigenetics in ocular vascular aging: an updated review
Vascular aging is an inevitable process with advancing age, which plays a crucial role in the pathogenesis of cardiovascular and microvascular...
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Investigation of Metabolic and Inflammatory Disorder in the Aging FGF21 Knockout Mouse
Aging is a physiological condition accomplished with persistent low-grade inflammation and metabolic disorders. FGF21 has been reported to act as a...
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APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12
Microglia are highly dynamic cells that play a critical role in tissue homeostasis through the surveillance of brain parenchyma and response to cues...
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Gliclazide Ameliorates Neuronal Injury by Attenuating Oxidative Stress in D-gal-Induced Senescent Cells and Aging Mice
Enhancement of oxidative stress and resultant neuronal injury play important roles in initiating cognitive impairment during the aging process. Thus,...
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Molecular Interplay of Oxidative Stress and Gut Microbiome in Aging
Oxidative stress results from an imbalance between reactive oxygen species production and the capacity of the organism to counteract them. These...
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PARP-2 mediates cardiomyocyte aging and damage induced by doxorubicin through SIRT1 Inhibition
Doxorubicin (DOX) is an anthracycline antibiotic used as an antitumor treatment. However, its clinical application is limited due to severe side...
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Aging, inflammaging and immunosenescence as risk factors of severe COVID-19
Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused by the novel severe acute respiratory syndrome coronavirus 2...
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Adiponectin deficiency accelerates brain aging via mitochondria-associated neuroinflammation
BackgroundA wide spectrum of changes occurs in the brain with age, from molecular to morphological aspects, and inflammation accompanied by...
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Response of Cellular Stress Toward the Hormetic Phytochemicals in Brain Aging
As people age, their brain cells undergo various types of stress that can lead to neurodegeneration and cognitive decline. One potential strategy for...
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The diseased kidney: aging and senescent immunology
Immunosenescence is the deterioration of the innate and adaptive immune systems associated with aging and is primarily characterized by a reduction...
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Healthcare on the brink: navigating the challenges of an aging society in the United States
The US healthcare system is at a crossroads. With an aging population requiring more care and a strained system facing workforce shortages, capacity...
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Towards a better preclinical cancer model – human immune aging in humanized mice
BackgroundPreclinical models are often used for cancer studies and evaluation of novel therapeutics. The relevance of these models has vastly...
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Toll-like receptor 4 (TLR4): new insight immune and aging
TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular...
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Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence
Renal tubular epithelial cell senescence plays a critical role in promoting and accelerating kidney aging and age-related renal fibrosis. Senescent...
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Long-term exposure to polystyrene microplastics triggers premature testicular aging
BackgroundPlastic pollution is greatly serious in the ocean and soil. Microplastics (MPs) degraded from plastic has threatened animals and humans...
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Genome-wide RNA polymerase stalling shapes the transcriptome during aging
Gene expression profiling has identified numerous processes altered in aging, but how these changes arise is largely unknown. Here we combined...
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Aging, Causes, and Rejuvenation of Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) undergo an age-related functional decline, which leads to a disruption of the blood system and contributes to the...
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Changes in human skin composition due to intrinsic aging: a histologic and morphometric study
Skin represents the main barrier against the external environment, but also plays a role in human relations, as one of the prime determinants of...
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Isolation of Phytohormone trans-Zeatin: Potential Oxidant Scavenger and Anti-Aging Compound
AbstractIn all parts of the world, dementia rates are rising rapidly, particularly in Western nations, where it accounts for roughly 60% of cases and...
