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The temporal mutational and immune tumour microenvironment remodelling of HER2-negative primary breast cancers
The biology of breast cancer response to neoadjuvant therapy is underrepresented in the literature and provides a window-of-opportunity to explore...
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Genomic and transcriptomic profiling reveal molecular characteristics of parathyroid carcinoma
Genomic and transcriptomic profiling has enhanced the diagnostic and treatment options for many cancers. However, the molecular characteristics of...
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Targeting metabolic flexibility via angiopoietin-like 4 protein sensitizes metastatic cancer cells to chemotherapy drugs
Overcoming multidrug resistance has always been a major challenge in cancer treatment. Recent evidence suggested epithelial-mesenchymal transition...
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Immunodiagnostics: A Perspective on Sensitivity, Specificity, and Stability of Tumor Antigens
Immunodiagnostics techniques are applied in clinical immunology to evaluate the disease state. These tests target disease-specific markers to detect...
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Hypoxia-Targeting Drugs as New Cancer Chemotherapy Agents: Molecular Insights
Solid tumors have a condition of low oxygen level, termed hypoxia. Hypoxia is regarded as one important characteristic of the tumor microenvironment....
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Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging
MOTS-c is a peptide encoded by the short open reading frame of the mitochondrial 12S rRNA gene. It is significantly expressed in response to stress...
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Identification of Anoikis-Related Genes in Spinal Cord Injury: Bioinformatics and Experimental Validation
Spinal cord injury (SCI) is a serious disease without effective therapeutic strategies. To identify the potential treatments for SCI, it is extremely...
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The R-enantiomer of ketorolac reduces ovarian cancer tumor burden in vivo
BackgroundRho-family GTPases, including Ras-related C3 botulinum toxin substrate 1 (Rac1) and cell division control protein 42 (Cdc42), are important...
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Genetics of Familial Combined Hyperlipidemia (FCHL) Disorder: An Update
Familial combined hyperlipidemia (FCHL) is one of the most common familial lipoprotein disorders of the lipoproteins, with a prevalence of 0.5% to 2%...
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Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank
Cardiometabolic diseases are the leading cause of death worldwide. Despite a known genetic component, our understanding of these diseases remains...
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The Metabolism of Cancer Cells During Metastasis
Metastasis is a lethal process that is the reason for most cancer-related deaths. It is an extensively researched field yet paradoxically is the...
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Modulating ferroptosis sensitivity: environmental and cellular targets within the tumor microenvironment
Ferroptosis, a novel form of cell death triggered by iron-dependent phospholipid peroxidation, presents significant therapeutic potential across...
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SARS-CoV-2 productively infects human brain microvascular endothelial cells
BackgroundThe emergence of the novel, pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global health emergency....
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Metabolic Reprogramming and the Control of Anoikis Resistance in Cancer
Normal epithelial and endothelial cells of the body undergo programmed cell death termed ‘anoikis’ when they are deprived of extra-cellular matrix...
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Reactive Oxygen Species–Mediated Cancer Progression and Metastasis
Reactive oxygen species (ROS) are involved in all stages of cancer and therefore their levels have a profound effect on the outcome of this disease....
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Cells and Structures Involved in Hair Follicle Regeneration: An Introduction
Introduction The hair follicle spans across the skin epidermis, dermis, and hypodermis and undergoes repeated cycles of growth (anagen), regression...
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Identification of Central Genes and Regulatory Pathways Associated with Hyperlipidemia in Rats
Hyperlipidemia is an independent risk factor for cardiovascular and cerebrovascular diseases. The transcriptomic data and the gene regulatory...
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Gene signatures, immune infiltration, and drug sensitivity based on a comprehensive analysis of m6a RNA methylation regulators in cervical cancer
BackgroundCervical cancer is the fourth most common cancer in women. N 6 -dimethyladenosine (m 6 A) mRNA methylation is closely associated with cervical...
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Portal vein tumor thrombosis in hepatocellular carcinoma: molecular mechanism and therapy
Portal vein tumor thrombosis (PVTT), a common complication of advanced hepatocellular carcinoma (HCC), remains the bottleneck of the treatments....
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Targeting the gut microbiota for cancer therapy
Growing evidence suggests that the gut microbiota modulates the efficacy and toxicity of cancer therapy, most notably immunotherapy and its...
