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The Protozoa
Protozoans are an extremely diverse group of unicellular animals. As free-living organisms they are found in virtually every ecological niche, such... -
Current problems in the management of AIDS patients
Human immunodeficiency virus infection has numerous clinical manifestations and affects patients from a broad spectrum of social, ethical, cultural...
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The pharmacokinetics of mefloquine when given alone or in combination with sulphadoxine and pyrimethamine in Thai male and female subjects
The kinetics of mefloquine were studied in 12 healthy Thai male and 12 healthy Thai female volunteers. Mefloquine (MQ) was administered either alone...
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Stage-specific sensitivity ofPlasmodium falciparum to antifolates
Highly synchronous cultures of Plasmodium falciparum were exposed to therapeutic concentrations of sulfadoxine or pyrimethamine at different...
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Microscopic and flow cytophotometric analysis of parasitemia in cultures ofPlasmodium falciparum vitally stained with Hoechst 33342 —application to studies of antimalarial agents
Conditions for rapid vital staining of Plasmodium falciparum infected human erythrocytes were 1 μg/ml of the dye Hoechst 33342 for 15 min in the...
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Prophylactic Antibiotics
Antibiotics consume approximately 35% of the total pharmacy budget in most hospitals with betalactam antibiotics comprising almost 60% of all... -
Sulphonamides and Sulphones
This chapter is focused on the sulphonamides and sulphones1 which are in current use as antimalarial drugs (mostly in combination with... -
Recent developments in chemotherapy and drug resistance
Resistance of human malaria parasites to drugs is of several types. It may be against: (1) compounds acting on pathways of folate metabolism, e.g.,... -
Evaluation of Drug Resistance in Man
Drug resistance in malaria can be defined as the “ability of a parasite strain to survive and/or multiply despite the administration and absorption... -
Evaluation of Drug Resistance in Man
Drug resistance in malaria can be defined as the “ability of a parasite strain to survive and/or multiply despite the administration and absorption... -
History and Current Status of Drug Resistance
Biologists and physicians define drug resistance in different terms (Peters 1970 a), the former being more concerned with the parasite and the latter... -
History and Current Status of Drug Resistance
Biologists and physicians define drug resistance in different terms (Peters 1970 a), the former being more concerned with the parasite and the latter... -
Drug Combinations
In this chapter discussion is limited to the different types of antimalarial drug combinations that have been described in experimental situations or... -
Clinical Trials — Phases III and IV and Field Trials
Well-tolerated and effective dosages of a new antimalarial in a number of precise indications will have been defined during phase II. Phase III... -
Clinical Trials – Phases III and IV and Field Trials
Well-tolerated and effective dosages of a new antimalarial in a number of precise indications will have been defined during phase II. Phase III... -
Use of Avian Malarias (In Vivo)
To estimate the full impact that research into avian malaria has played in the development of knowledge of the parasite, its metabolism, malaria... -
Use of Avian Malarias (In Vivo)
To estimate the full impact that research into avian malaria has played in the development of knowledge of the parasite, its metabolism, malaria... -
Malaria control
Malaria either affects or threatens several hundred million people. Each year, it causes more than a million deaths [1, 2]. It has considerable...