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Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
Most common central nervous system disorders — such as depression, bipolar disorder and schizophrenia — seem to be polygenic in origin, and the most...
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Pharmacogenomics of multigenic diseases: Sex-specific differences in disease and treatment outcome
Numerous genetic variations have been shown to affect disease susceptibility and drug response. Pharmacogenomics aims at improving therapy on the...
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Memory and the Regulation of Chromatin Structure
One of the striking behavioral observations to emerge from the study of memory storage is that long-term memory - lasting days - differs...
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Disruption of CREB function in brain leads to neurodegeneration
Control of cellular survival and proliferation is dependent on extracellular signals and is a prerequisite for ordered tissue development and...
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Striatal glutamatergic mechanisms and extrapyramidal movement disorders
The nonphysiologic stimulation of striatal dopaminergic receptors, as a result of disease- or drug-related denervation or intermittent excitation,...
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DNA polymorphisms in potential regulatory elements of the CFTR gene alter transcription factor binding
Over one thousand mutations have been identified to date in the cystic fibrosis transmembrane conductance regulator gene ( CFTR ); however, about 5–10%...
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The mouse: genetics meets behaviour
Genetic studies in the mouse are important in the elucidation of molecular pathways that underlie behaviour. The advantages of the mouse for...
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Distribution and partial characterization of CREB-like immunoreactivity in the medicinal leech Hirudo
The presence and distribution of immunoreactivity to the cyclic AMP response element binding protein (CREB) were determined in the central nervous...
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Map** murine loci for physical dependence on ethanol
Rationale: Alcoholism is associated with withdrawal (physical dependence), tolerance, or a maladaptive pattern of alcohol (ethanol) use. The...
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NOBEL LECTURE: The Molecular Biology of Memory Storage: A Dialog Between Genes and Synapses
The biology of learning, and short-term and long-term memory, as revealed by Aplysia and other organisms, is reviewed.
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Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
We investigated the involvement of extracellular signal-regulated protein kinases (ERK) within spinal neurons in producing pain hypersensitivity....
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Novel variants in the promoter region of the CREB gene in schizophrenic patients
Cyclic AMP-responsive element-binding protein (CREB) is one of the messenger molecules involved in intracellular signal transduction pathways used...
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Ubiquitin-mediated proteolysis in learning and memory
Sensitization of defensive reflexes in Aplysia is a simple behavioral paradigm for studying both short- and long-term memory. In the marine mollusk,...
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Quantitative trait loci analysis affecting contextual conditioning in mice
In an extensive backcross of mice between C3H/HeJ (C3H) and C57BL/6J (B6), we sought to map genes that influence learning and memory as measured by...
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Priming events and retrograde injury signals
Successful axon regeneration requires that signals from the site of injury reach the nucleus to elicit changes in transcription. In spite of their...