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Cholera and Typhoid Vaccines
The recent spread of cholera in the Americas and the emergence of Vibrio cholerae 0139 in Asia have stimulated researchers to design efficient...
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Clinical Pharmacology of Sulfonylureas
In vitro studies using the perfused rat pancreas and in vivo studies using the hyperglycemic clamp have demonstrated that sulfonylureas stimulate... -
Polymer Microspheres for Vaccine Delivery
Every year millions of people, particularly children, die of diseases for which a vaccine exists (Walsh, 1988; Warren, 1989). Countless others are... -
Reassessment of the impact of mucosal immunity in infection with the human immunodeficiency virus (HIV) and design of relevant vaccines
The development of vaccines that would induce specific immune responses in the genital tract secretions would have far-reaching implications for not...
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BCG Vaccine: The Next Generation of Targeted Drug Delivery Systems
The relatively recent recognition of the value of bacillus Calmette-Guérin (BCG) as a general immunostimulant and its introduction into clinical... -
Medical Applications of Hyaluronan and its Derivatives
Hyaluronan (hyaluronic acid) is a natural polyanionic polysaccharide (glycosaminoglycan) present in the intercellular matrix of most vertebrate... -
Introduction: State of the Art and Design Principles of Contrast Media
The concept of contrast media (CM) emerged shortly after Roentgen’s discovery. A large number of radiopaque compounds were tested in vivo; of these,... -
Humoral mediated macrophage response during tumour growth
Reticuloendothelial (RE) phagocytic and circulating plasma opsonic activity was evaluated in rats transplanted with the Walker 256 carcinoma tumour...