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Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis
BackgroundUpregulation of the mitogen-activated protein kinase (MAPK) cascade is common in hepatocellular carcinoma (HCC). Neuroblastoma RAS viral...
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Cellular senescence in neuroblastoma
Neuroblastoma is a tumour that arises from the sympathoadrenal lineage occurring predominantly in children younger than five years. About half of the...
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Efficacy of stem cell secretome in the treatment of traumatic brain injury: A systematic review and meta-analysis of preclinical studies
Traumatic brain injury (TBI) remains a public health challenge and represents one of the major contributors to disability and mortality worldwide...
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Multicancer screening test based on the detection of circulating non haematological proliferating atypical cells
Backgroundthe problem in early diagnosis of sporadic cancer is understanding the individual’s risk to develop disease. In response to this need,...
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Post-translational modifications on the retinoblastoma protein
The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour...
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Study protocol of the LARK (TROG 17.03) clinical trial: a phase II trial investigating the dosimetric impact of Liver Ablative Radiotherapy using Kilovoltage intrafraction monitoring
BackgroundStereotactic Ablative Body Radiotherapy (SABR) is a non-invasive treatment which allows delivery of an ablative radiation dose with high...
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Atorvastatin facilitates chemotherapy effects in metastatic triple-negative breast cancer
BackgroundMetastatic triple-negative breast cancer (mTNBC) is treated mainly with chemotherapy. However, resistance frequently occurs as tumours...
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Histopathology of Hereditary Diffuse Gastric Cancer: From Grossing and 3D Microscopy to Immunophenotypic and Molecular Profiling
Hereditary diffuse gastric cancer (HDGC) is one of the three inherited syndromes that affect primarily the stomach, besides gastric adenocarcinoma...
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Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management
Melatonin, the ‘hormone of darkness’ is a neuronal hormone secreted by the pineal gland and other extra pineal sites. Responsible for the circadian...
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Silencing PKM2 Attenuates Brain Injury Induced by Status Epilepticus by Inhibiting the AKT/mTOR Pathway and the NLRP3 Inflammasome
PKM2 is a glycolytic pyruvate kinase isoenzyme, and its role in neurological diseases has been published. However, the role and mechanism of PKM2 in...
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Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil
BackgroundHand-foot syndrome (HFS) is a serious dose-limiting cutaneous toxicity of capecitabine-containing chemotherapy, leading to a deteriorated...
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Tumor Inflammatory Microenvironment in Lung Cancer: Heterogeneity and Implications
Tumor diseases continue to pose a significant global health challenge, accounting for a substantial portion of human mortality. The formation and...
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Wnt3a/GSK3β/β-catenin Signalling Modulates Doxorubicin-associated Memory Deficits in Breast Cancer
Background: Chemobrain is widespread in breast cancer patients receiving chemotherapy. However, the exact mechanism, especially the associated...
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Akkermansia muciniphila, which is enriched in the gut microbiota by metformin, improves cognitive function in aged mice by reducing the proinflammatory cytokine interleukin-6
BackgroundMetformin, a type 2 diabetes treatment, improves the cognitive function of aged mice; however, whether the protective effects of metformin...
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Mouse Melanoma Model in Tumor Vaccines and Immunotherapy Research
Efficacy of novel cancer immunization protocols could be tested in cell line-derived xenograft tumor models (CDX), which are based on the...
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Retrovirus
Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immunodeficiency syndrome (AIDS). AIDS is one of the most devastating...
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Age distribution and a multi-stage theory of carcinogenesis: 70 years on
The Armitage Doll model demonstrates that the impact of age-dependent exposure to carcinogenic factors depends on whether the induced change occurs...
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Vitamin K2 protects against aluminium chloride-mediated neurodegeneration
Recent studies have shown that, coupled with other environmental factors, aluminium exposure may lead to neurodegeneration resulting in cognitive...
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Mitochondrial oxidative phosphorylation in cutaneous melanoma
The Warburg effect in tumour cells is associated with the upregulation of glycolysis to generate ATP, even under normoxic conditions and the presence...
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Cancer progression and the invisible phase of metastatic colonization
Metastatic dissemination occurs very early in the malignant progression of a cancer but the clinical manifestation of metastases often takes years....
