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The inhibitory role of stigmasterol on tumor growth by inducing apoptosis in Balb/c mouse with spontaneous breast tumor (SMMT)
BackgroundBreast cancer is one of the most common types of cancer in women worldwide. Anti-apoptotic activity of cancer cells is considered the main...
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Immunological and tumor-intrinsic mechanisms mediate the synergistic growth suppression of experimental glioblastoma by radiotherapy and MET inhibition
The hepatocyte growth factor (HGF)/MET signaling pathway has been proposed to be involved in the resistance to radiotherapy of glioblastoma via...
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Dopamine receptor D3 is related to prognosis in human hepatocellular carcinoma and inhibits tumor growth
BackgroundDopamine receptors have been reported to play important roles in cancer progression. However, the role of dopamine receptor D3 (DRD3) in...
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E-cadherin expression in the tumor microenvironment of advanced epidermal growth factor receptor-mutant lung adenocarcinoma and the association with prognosis
BackgroundThe expression of programmed death-ligand 1 (PD-L1), tumor-infiltrating lymphocytes (TILs), E-cadherin, and vimentin in lung cancer tumor...
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Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 ...
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The Role of Exosomes in Tumor Metastasis
Exosomes, extracellular vesicles featuring phospholipid bilayers, play essential roles in cell–cell communication; tumor microenvironment (TME)...
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Loss of RACK1 promotes glutamine addiction via activating AKT/mTOR/ASCT2 axis to facilitate tumor growth in gastric cancer
BackgroundMetabolic reprogramming is closely related to the development of gastric cancer (GC), which remains as the fourth leading cause of...
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Tumor Associated Neutrophils (TANs) and Cancer Metastasis
Neutrophils play an important role in human innate immunity, but their role in cancer biology was underestimated. It was seen that a high...
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CircZNF215 promotes tumor growth and metastasis through inactivation of the PTEN/AKT pathway in intrahepatic cholangiocarcinoma
BackgroundIncreasing evidence shows that circular RNAs (circRNAs), a novel class of noncoding RNAs, play a crucial role in the development of...
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Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma
Signal transducer and activator of transcription 3 (STAT3) plays an important role in the occurrence and progression of tumors, leading to resistance...
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ALDOC- and ENO2- driven glucose metabolism sustains 3D tumor spheroids growth regardless of nutrient environmental conditions: a multi-omics analysis
BackgroundMetastases are the major cause of cancer-related morbidity and mortality. By the time cancer cells detach from their primary site to...
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Aberrant accumulation of NIK promotes tumor growth by dysregulating translation and post-translational modifications in breast cancer
BackgroundIn vivo investigations with cancer cells have powerful tools to discover cancer progression mechanisms and preclinical candidate drugs....
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Tumor-on-a-Chip: Microfluidic Models of Hypoxic Tumor Microenvironment
Cancer is ranked as the deadliest prime health issue, albeit with mammoth efforts to panacea the ailment. To subdue the vast constraints in tumor...
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Loss-of-function of the hippo transducer TAZ reduces mammary tumor growth through a myeloid-derived suppressor cell-dependent mechanism
TAZ, one of the key effectors in the Hippo pathway, is often dysregulated in breast cancer, leading to cancer stemness, survival, and metastasis....
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Tumor Immunology and Immunotherapy
Understanding immune mechanisms in cancer and immunotherapy has made cancer diagnosis and treatment more effective. The immune system can recognize...
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Modeling of Tumor Growth with Input from Patient-Specific Metabolomic Data
Advances in omic technologies have provided insight into cancer progression and treatment response. However, the nonlinear characteristics of cancer...
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Ketogenic diets slow melanoma growth in vivo regardless of tumor genetics and metabolic plasticity
BackgroundGrowing evidence supports the use of low-carbohydrate/high-fat ketogenic diets as an adjunctive cancer therapy. However, it is unclear...
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Introduction to Tumor Microenvironment
The knowledge of tumor microenvironment (TME) has grown exponentially in recent decades. TME is a complex milieu with an essential role in tumor...
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Phosphatidylserine and/or Sialic Acid Modified Liposomes Increase Uptake by Tumor-associated Macrophages and Enhance the Anti-tumor Effect
DOX liposomes have better therapeutic effects and lower toxic side effects. The targeting ability of liposomes is one of the key factors affecting...
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Platelets induce CD39 expression in tumor cells to facilitate tumor metastasis
BackgroundTumor cells continue to evolve the metastatic potential in response to signals provided by the external microenvironment during metastasis....
