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DNA Damage and Chromatin Rearrangement Work Together to Promote Neurodegeneration
Neurodegenerative diseases have a complex origin and are composed of genetic and environmental factors. Both DNA damage and chromatin rearrangement...
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Treadmill running and Levisticum Officinale extract protect against LPS-induced memory deficits by modulating neurogenesis, neuroinflammation and oxidative stress
Neuroinflammation plays an essential role in the pathogenesis of Alzheimer’s disease. The preventive effect of physical exercise on attenuating...
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Dysfunction, oxidative stress markers, and cytokine expression in the placentae of mice experimentally infected with Neospora caninum
Neosporosis is the major cause of abortion and reproductive failures in cattle, leading to significant economic losses. In this study, we evaluated...
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Black Seed Oil-Based Curcumin Nanoformulations Ameliorated Cuprizone-Induced Demyelination in the Mouse Hippocampus
Multiple sclerosis (MS) is a neurodegenerative disease characterized by the demyelination of nerves, axonal damage, and neuroinflammation. Cognition...
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Superoxide dismutase activity as a predictor of adverse outcomes in patients with nonischemic dilated cardiomyopathy
Oxidative stress contributes to progression of heart failure (HF). The present study analyzed the efficacy of the activities of superoxide dismutase...
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Prolonged Exposure to High Glucose Induces Premature Senescence Through Oxidative Stress and Autophagy in Retinal Pigment Epithelial Cells
Chronic hyperglycemia involves persistent high-glucose exposure and correlates with retinal degeneration. It causes various diseases, including...
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Genistein Alleviates Oxidative Stress and Inflammation in the Hypothalamic Paraventricular Nucleus by Activating the Sirt1/Nrf2 Pathway in High Salt-Induced Hypertension
Hypertension caused by a high-salt (HS) diet is one of the major causes of cardiovascular diseases. Underlining pathology includes oxidative stress...
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ROS-Mediated Apoptosis in Cancer
Redox homeostasis is defined as a balance between reactive oxygen species (ROS) production and ROS elimination. Intracellular ROS are produced during...
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Nicotinamide mononucleotide supplementation mitigates osteopenia induced by modeled microgravity in rats
Exposure to weightlessness causes severe osteopenia, resulting in raised fracture risk. The current study aimed to investigate whether nicotinamide...
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Understanding the Functions of Longevity Genes in Drosophila
The fruit fly, Drosophila melanogaster, has been an excellent model organism to study aging and longevity. A number of genes affecting longevity have...
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Neuroprotective Effect of a Multistrain Probiotic Mixture in SOD1G93A Mice by Reducing SOD1 Aggregation and Targeting the Microbiota-Gut-Brain Axis
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the selective loss of motor neurons. A bidirectional...
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Protective effects of diosmin on doxorubicin-induced testicular toxicity in rat
Doxorubicin (DOX) can be applied to treat several cancers. DOX-induced oxidative stress causes testicular damage. Diosmin (DIO), as a potent...
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Association of Oxidative Stress on Cognitive Function: A Bidirectional Mendelian Randomisation Study
The purpose of this study was to investigate the relationship between oxidative stress and cognitive function, encompassing cognitive performance,...
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Neuroprotective effects of silymarin in 3-nitropropionic acid-induced neurotoxicity in male mice: improving behavioral deficits by attenuating oxidative stress and neuroinflammation
3-Nitropropionic acid (3-NP) is strongly believed to be an irreversible inhibitor of mitochondrial complex II, leading to neural damage. This study...
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Effectiveness of hesperidin against toxic effect of silver nanoparticles on the brain via apoptotic/antiapoptotic pathway in adult albino rats
ObjectiveThe existing work aims to assess the role of hesperidin against silver oxide nanoparticles-induced toxic changes in brain of adult albino...
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Astaxanthin treatment decreases pro‐inflammatory cytokines and improves reproductive outcomes in patients with polycystic ovary syndrome undergoing assisted reproductive technology: A randomized clinical trial
Research questionIn a randomized, triple-blind, placebo-controlled clinical trial (RCT), we investigated the effect of astaxanthin (AST) on...
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Betaine alleviates doxorubicin-related cardiotoxicity via suppressing oxidative stress and inflammation via the NLRP3/SIRT1 pathway
Cardiotoxicity is one of the side effects of the anti-cancer drug doxorubicin (DOX) that limits its clinical application. Betaine (BT) is a natural...
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Hesperetin-Based Hydrogels Protect the Skin against UV Radiation-Induced Damage
UV radiation can cause damages, such as erythema, skin photoaging, and carcinogenesis. The adoption of protective measures against sun exposure is...
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Estrone-mediated lowering of ROS and NOX4 improves endothelial function in ovariectomized wistar rats
Estrone (E1) constitutes the primary component in oral conjugated equine estrogens (CEEs) and serves as the principal estrogen precursor in the...
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Oxidative Stress and Thyroid Disorders
Physiological role of reactive oxygen species (ROS) in the biosynthesis of thyroid hormone (TH) is well known; however, ROS deregulation is noted in...