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Ligand-Directed Chemical Labeling for Visualizing and Analyzing AMPA Receptors in Neurons
Glutamate receptors have essential roles in brain functions, such as memory, learning, and cognition. Recent studies have revealed that strict...
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Application of Deep Learning for Studying NMDA Receptors
Artificial intelligence underwent remarkable advancement in the past decade, revolutionizing our way of thinking and unlocking unprecedented...
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Development of human-machine language interfaces for the visual analysis of complex biologics and RNA modalities and associated experimental data
The advent of recombinant protein-based therapeutic agents in the 1980s and subsequent waves of innovation in molecular biology and engineering of...
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Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common and deadly cancers in the world. The therapeutic outlook for HCC patients has significantly...
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New Directions in Coupling Chemistry
Palladium-mediated cross-couplings are established as a core synthetic technology within the pharmaceutical industry for the assembly of biologically...
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Small Activating RNA Therapy for Angiogenesis
RNA activation has been known about for 15 years. In essence, it means activating the endogenous specific gene of cells by small RNA, which targets...
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Multiple Applications of a Novel Fluorescence Probe with Large Stokes Shift and Sensitivity for Rapid H2S Detection
Herein, a novel fluorescence probe Fla-DNP based on flavonol has been designed and synthesized for rapid, specific detection of H 2 S. With the...
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Recent advances in structural types and medicinal chemistry of PARP-1 inhibitors
Poly (ADP-ribose) Polymerase-1 (PARP-1) is a member of 17 membered PARP family having diversified biological functions such as synthetic lethality,...
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Mining genomes to illuminate the specialized chemistry of life
All organisms produce specialized organic molecules, ranging from small volatile chemicals to large gene-encoded peptides, that have evolved to...
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An Overview of Subchronic and Chronic Toxicology
This chapter will explore the regulatory requirement for subchronic and chronic toxicology studies, their design and purpose. The various routes of...
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Enhanced biopharmaceutical performance of brick dust molecule nilotinib via stabilized amorphous nanosuspension using a facile acid–base neutralization approach
“Brick dust” compounds have high lattice energy as manifested by the poor aqueous solubility and suboptimal bioavailability. Nilotinib being a weakly...
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Small-Molecule Pharmacology of Epithelial Inward Rectifier Potassium Channels
Inward rectifier potassium (Kir) channels play fundamental roles in epithelial fluid and electrolyte transport in several organ systems and represent...
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Radiopharmaceutical Discovery with 11CO2-Fixation Methods Inspired by Green Chemistry
Efforts to use sustainable and abundant feedstocks for chemical synthesis have produced efficient methods for incorporating carbon dioxide into small...
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The Application of Box-Behnken-Design in the Optimization of Kinetic Spectrophotometry and Computational Studies to Determine and Assessing Eco-Scale to Green Analytical Chemistry for Labetalol
PurposeThe study is aimed at the quantitative analysis of Labetalol utilizing Box-Benken design, where higher order response surfaces are generated...
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Nano-mediated strategy for targeting and treatment of non-small cell lung cancer (NSCLC)
Lung cancer is the most common type of cancer, with over 2.1 million cases diagnosed annually worldwide. It has a high incidence and mortality rate,...
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Medicinal Chemistry
Medicinal chemistry is concerned with the synthesis of small molecules which are passed to biologists for testing against drug targets. The vastness...
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New Therapeutic Modalities: Transforming Drug Discovery and Development
Drug discovery and development has undergone an impressive transformation over recent years driven by the emergence of new chemical modalities....
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Innovative Strategies in Drug Discovery and Pharmacoinformatics
Drug discovery comprises all the activities involved in transforming a compound from a drug candidate to a product approved for marketable form and...
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Identification and characterization of two DMD pedigrees with large inversion mutations based on a long-read sequencing pipeline
Pathogenic large inversions are rarely reported on DMD gene due to the lack of effective detection methods. Here we report two DMD pedigrees and...
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Sesamol as a potent anticancer compound: from chemistry to cellular interactions
Sesamol (SM), a well-known component isolated from sesame seeds ( Sesamum indicum ), used in traditional medicines in treating numerous ailments....
