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Blockade of aryl hydrocarbon receptor restricts omeprazole-induced chronic kidney disease
AbstractChronic kidney disease (CKD) is the 16th leading cause of mortality worldwide. Clinical studies have raised that long-term use of omeprazole...
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The Role of Nitric Oxide in the Etiopathogenesis of Preeclampsia
Preeclampsia (PE) is a severe pregnancy complication that presents mostly after twenty weeks of gestation. It can be diagnosed by increased systolic...
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Overexpression of SP1 restores autophagy to alleviate acute renal injury induced by ischemia-reperfusion through the miR-205/PTEN/Akt pathway
BackgroundAcute kidney injury (AKI) is a major kidney disease with poor clinical outcome. SP1, a well-known transcription factor, plays a critical...
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Shear wave elastography in chronic kidney disease – the physics and clinical application
Chronic kidney disease is a leading public health problem worldwide. The global prevalence of chronic kidney disease is nearly five hundred million...
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Renal ischemic adverse drug events related to tranexamic acid in women of child-bearing age: an analysis of pharmacovigilance data
PurposeIn response to a large trial, the World Health Organization broadened their recommendation on tranexamic acid to be used for post-partum...
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Drug Dose and Therapy Individualization
This chapter discusses how drug dosing depends on a variety of factors including those of the drug itself and those of the recipient. Principles of...
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Erythropoietin in the Treatment of Anaemia
Anaemia is a prevalent clinical presentation in individuals suffering from chronic kidney disease (CKD). This issue is linked to an elevated...
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Microfilaruria of Dirofilaria immitis in a dog from Italy
Dirofilaria immitis is a mosquito-borne nematode-causing canine heartworm disease, with adult worms localized in the pulmonary arteries and right...
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Urologic surveillance of persons with spinal cord injuries – a sco** review
Study designSco** review - standardized according to the Equator-network and the Prisma-Statement guidelines with PRISMA-ScR.
Objectives ...
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Case report of oxalate nephropathy in a patient with pancreatic metastases from renal carcinoma
BackgroundPatients with metastatic renal carcinoma frequently have pre-existing renal impairment and not infrequently develop worsening renal...
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Pharmacokinetics of polymyxin B in different populations: a systematic review
Background and objectivesDespite being clinically utilized for the treatment of infections, the limited therapeutic range of polymyxin B (PMB), along...
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Estimation of renal function in adult outpatients with normal serum creatinine
ObjectiveThe aim of this study was to estimate the prevalence of renal insufficiency using estimated glomerular filtration rate (eGFR) among adult...
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Prenatal Inflammatory Exposure Predisposes Offspring to Chronic Kidney Diseases Via the Activation of the eIF2α-ATF4 Pathway
It has recently become more recognized that renal diseases in adults can originate from adverse intrauterine (maternal) environmental exposures....
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Enoxaparin for VTE thromboprophylaxis during inpatient rehabilitation care: assessment of the standard fixed dosing regimen
BackgroundWe aimed to examine the efficiency of fixed daily dose enoxaparin (40 mg) thromboprophylaxis strategy for patients undergoing inpatient...
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Application of metagenomic next-generation sequencing in the diagnosis and treatment guidance of Pneumocystis jirovecii pneumonia in renal transplant recipients
Pneumocystis jirovecii pneumonia (PJP) is difficult to be diagnosed, so this study explored if PJP could be diagnosed by metagenomic next-generation...
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The Classical and Nonclassical Renin-Angiotensin-Aldosterone System in Liver Cirrhosis
In chronic liver disease, excess hepatic deposition of extracellular matrix, the ensuing development of cirrhosis, the associated renal dysfunction,...
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Cell Cycle Arrest Biomarkers in the Intensive Care Unit
AKI is a clinical syndrome mainly manifested as a sharp decline in renal function, which is a common complication in the ICU and is characterized by...
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Clinical outcome of renal cancer patients who early interrupted immunotherapy due to serious immune-related adverse events. Meet-Uro 13 trial on behalf of the MeetUro investigators
BackgroundSevere immune-related Adverse Events (irAEs) develop in 10–27% of patients treated with Immune-Oncology (IO) [Powles (Lancet 391:748–757,...
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mTOR inhibitor reduces nontumour-related death in liver transplantation for hepatocellular carcinoma
Sirolimus is a regularly applied immunosuppressant for patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). Sirolimus...
