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Investigation of Controlled Release Molecular Mechanism of Oil Phase in Spilanthol Emulsion: Development and In Vitro, In Vivo Characterization
The aim of the present study was to develop a spilanthol emulsion and investigate the effect of oil and drug physicochemical properties on drug...
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Probing the Molecular-Level Interactions in an Active Pharmaceutical Ingredient (API) - Polymer Dispersion and the Resulting Impact on Drug Product Formulation
PurposeAn investigation of underlying mechanisms of API-polymer interaction patterns has the potential to provide valuable insights for selecting...
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Melt Extrusion
Techniques to overcome poor aqueous solubility of active pharmaceutical ingredients (APIs) continue to gain interest, with a reported 30% of marketed...
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Continuous Manufacturing and Molecular Modeling of Pharmaceutical Amorphous Solid Dispersions
Amorphous solid dispersions enhance solubility and oral bioavailability of poorly water-soluble drugs. The escalating number of drugs with poor...
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Nanoemulsions: A Potential Advanced Nanocarrier Platform for Herbal Drug Delivery
Nanotechnology is an emerging science in pharmaceutical technology with numerous opportunities to address the various challenges in drug delivery....
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A Review on Physicochemical Properties of Polymers Used as Filaments in 3D-Printed Tablets
Three-dimensional (3D) printing technology has presently been explored widely in the field of pharmaceutical research to produce various conventional...
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Spray-Drying Technology
This chapter provides an in-depth review of spray-drying technology and its application to the formulation of poorly water-soluble drugs. In the...
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Technological Innovations in Pharmaceutical Drug Nanocrystals
Nanocrystals are innovative drug delivery systems to improve solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. In this...
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A novel class of indole derivatives: enhanced bioavailability, permeability, and antioxidant efficacy for thromboembolic disease therapy
Free radicals like reactive oxygen species (ROS) and reactive nitrogen species (RNS) cause cellular damage and contribute to thromboembolic diseases...
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Engineering mannose-functionalized nanostructured lipid carriers by sequential design using hybrid artificial intelligence tools
Nanostructured lipid carriers (NLCs) hold significant promise as drug delivery systems (DDS) owing to their small size and efficient drug-loading...
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Enhanced Oral Bioavailability of Isoformononetin Through Nanoemulsion: Development, Optimization, and Characterization
BackgroundIsoformononetin (IFN) is a methoxyl derivative of daidzein and has been stated as a potent osteogenic isoflavone. However, IFN has low oral...
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Antiretroviral action of Rosemary oil-based atazanavir formulation and the role of self-nanoemulsifying drug delivery system in the management of HIV-1 infection
Atazanavir or ATV is an FDA-approved, HIV-1 protease inhibitor that belongs to the azapeptide group. Over time, it has been observed that ATV can...
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Solvent-Casted Films to Assist Polymer Selection for Amorphous Solid Dispersions During Preclinical Studies: In-vitro and In-vivo Exploration
PurposeThe use of two solvent-casted film methods to select optimal polymer compositions for amorphous solid dispersions prepared to support...
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Gastroretentive Sustained-Release Tablets Combined with a Solid Self-Micro-Emulsifying Drug Delivery System Adsorbed onto Fujicalin®
Gastroretentive drug delivery systems (GRDDS) get retained in the stomach for a long time, thus facilitating the absorption of drugs in the upper...
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Applying polyvinyl alcohol to the preparation of various nanoparticles
BackgroundProviding nanoscale monodisperse particles in nanoparticle-based drug delivery systems (DDSs) is an important issue in particle synthesis....
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Effects of Formulation and Manufacturing Process on Drug Release from Solid Self-emulsifying Drug Delivery Systems Prepared by High Shear Mixing
This study sought to investigate the influence of formulation and process factors of the high shear mixing (HSM) on the properties of solid...
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Particle preparation of pharmaceutical compounds using supercritical antisolvent process: current status and future perspectives
The low aqueous solubility and subsequently slow dissolution rate, as well as the poor bioavailability of several active pharmaceutical ingredients...
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Calcium Ion-Sodium Alginate-Piperine-Based Microspheres: Evidence of Enhanced Encapsulation Efficiency, Bio-Adhesion, Controlled Delivery, and Oral Bioavailability of Isoniazid
Isoniazid (INH) is a first-line chemotherapeutic drug employed in the management of tuberculosis. However, its extensive first-pass metabolism,...
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Coformer-Dependent Physical Stability in a Series of Naringenin-Based Coamorphous Materials with Caffeine, Theophylline, and Theobromine
PurposeTo investigate the production and physical stability of coamorphous materials (CAM) of naringenin (NAR) and coformers-caffeine, theophylline...
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Experimental Solubility, Thermodynamic/Computational Validations, and GastroPlus-Based In Silico Prediction for Subcutaneous Delivery of Rifampicin
We focused to explore a suitable solvent for rifampicin (RIF) recommended for subcutaneous (sub-Q) delivery [ethylene glycol (EG), propylene glycol...
