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The functional roles of the circRNA/Wnt axis in cancer
CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were...
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Recent advances of m6A methylation in skeletal system disease
Skeletal system disease (SSD) is defined as a class of chronic disorders of skeletal system with poor prognosis and causes heavy economic burden....
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RNA-binding proteins and exoribonucleases modulating miRNA in cancer: the enemy within
Recent progress in the investigation of microRNA (miRNA) biogenesis and the miRNA processing machinery has revealed previously unknown roles of...
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N6-methyladenosine methylation in kidney injury
Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and development of kidney...
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Plasma cell signatures predict prognosis and treatment efficacy for lung adenocarcinoma
PurposeThis study aims to identify key genes regulating tumor infiltrating plasma cells (PC) and provide new insights for innovative immunotherapy....
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Sperm epigenetics and male infertility: unraveling the molecular puzzle
BackgroundThe prevalence of infertility among couples is estimated to range from 8 to 12%. A paradigm shift has occurred in understanding of...
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Therapeutic importance and diagnostic function of circRNAs in urological cancers: from metastasis to drug resistance
Circular RNAs (circRNAs) are a member of non-coding RNAs with no ability in encoding proteins and their aberrant dysregulation is observed in...
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Circulating tumor nucleic acids: biology, release mechanisms, and clinical relevance
BackgroundDespite advances in early detection and therapies, cancer is still one of the most common causes of death worldwide. Since each tumor is...
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An insight into thymidylate synthase inhibitor as anticancer agents: an explicative review
Cancer, a widespread challenge to global health, remains a puzzle of intricate molecular dynamics. This review article delves into the mystery of...
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Parkinson’s Disease and MicroRNAs: A Duel Between Inhibition and Stimulation of Apoptosis in Neuronal Cells
Parkinson’s disease (PD) is one of the most prevalent diseases of central nervous system that is caused by degeneration of the substantia nigra’s...
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Development Immune-Related Prognostic Model and LncRNA-miRNA-mRNA ceRNA Network for Cervical Cancer
AbstractCervical cancer is a serious threat to women’s health. The aim of this study was to provide new insights into the mechanism of cervical...
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Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches
Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among patients with colorectal cancer (CRC). Although immunotherapy...
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MicroRNAs as the critical regulators of autophagy-mediated cisplatin response in tumor cells
Chemotherapy is one of the most common therapeutic methods in advanced and metastatic tumors. Cisplatin (CDDP) is considered as one of the main...
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Current advances and future perspectives on the functional roles and clinical implications of circular RNAs in esophageal squamous cell carcinoma: more influential than expected
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive gastrointestinal cancers with high incidence and mortality. Therefore, it is...
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Exosomes: A Cellular Communication Medium That Has Multiple Effects On Brain Diseases
Exosomes, as membranous vesicles generated by multiple cell types and secreted to extracellular space, play a crucial role in a range of brain...
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Emerging role of non-coding RNAs in neuroinflammation mediated by microglia and astrocytes
Neuroinflammation has been implicated in the initiation and progression of several central nervous system (CNS) disorders, including Alzheimer’s...
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Long non-coding RNAs as critical regulators and novel targets in cervical cancer: current status and future perspectives
Cervical cancer is among the leading causes of cancer-associated mortality in women. In spite of vaccine availability, improved screening procedures,...
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Hsa_circ_0002348 regulates trophoblast proliferation and apoptosis through miR-126-3p/BAK1 axis in preeclampsia
BackgroundPreeclampsia is a common pregnancy complication characterized by high blood pressure and damage to organs. Abnormal placenta and vascular...
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The regulation of necroptosis and perspectives for the development of new drugs preventing ischemic/reperfusion of cardiac injury
In the last 10 years, mortality from acute myocardial infarction (AMI) has not significantly decreased. This situation is associated with the absence...
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Exercise mimetics: a novel strategy to combat neuroinflammation and Alzheimer’s disease
Neuroinflammation is a pathological hallmark of Alzheimer’s disease (AD), characterized by the stimulation of resident immune cells of the brain and...
