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Membrane-stabilizing and protective effects of curcumin in a rotenone-induced rat model of Parkinson disease
Parkinson disease (PD) is a chronic progressive neurodegenerative disease characterized by both motor and non-motor features. Numerous risk factors...
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P2X7-mediated alteration of membrane fluidity is associated with the late stages of age-related macular degeneration
We have shown deficits in monocyte phagocytosis from patients with age-related macular degeneration (AMD). Cell membrane fluidity is known to affect...
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Role of BCR and FNBP1 Proteins in Phagocytosis as a Model of Membrane Rearrangements with Chronic Myelogenous Leukemia
Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm resulting from the emergence of abnormal hematopoietic stem cells carrying a...
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Study on the regulatory mechanism of latent membrane protein 2A on GCNT3 expression in nasopharyngeal carcinoma
O-Glycan synthesis enzyme glucosaminyl (N-acetyl) transferase 3 (GCNT3) is closely related to the occurrence and development of various...
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Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure
IL-1α is an intracellular danger signal (DAMP) released by macrophages contributing to the development of silica-induced lung inflammation. The exact...
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Basement membrane-related MMP14 predicts poor prognosis and response to immunotherapy in bladder cancer
BackgroundBasement membrane (BM) is an important component of the extracellular matrix, which plays an important role in the growth and metastasis of...
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Universal redirection of CAR T cells against solid tumours via membrane-inserted ligands for the CAR
The effectiveness of chimaeric antigen receptor (CAR) T cell therapies for solid tumours is hindered by difficulties in the selection of an effective...
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Arginine-linked HPV-associated E7 displaying bacteria-derived outer membrane vesicles as a potent antigen-specific cancer vaccine
BackgroundBacteria-based cancer therapy have demonstrated innovative strategies to combat tumors. Recent studies have focused on gram-negative...
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The role of inner nuclear membrane proteins in tumourigenesis and as potential targets for cancer therapy
Despite significant advances in our understanding of tumourigenesis and cancer therapeutics, cancer continues to account for 30% of worldwide deaths....
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Simultaneous Detection of Inflammasome Activation and Membrane Damage During Pyroptosis
Pyroptosis is a highly regulated inflammatory form of cell death that plays a role in many different diseases, including cancer. Pyroptosis was...
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Eicosapentaenoic acid loaded silica nanoemulsion attenuates hepatic inflammation through the enhancement of cell membrane components
BackgroundLiver inflammation is a multistep process that is linked with cell membrane fatty acids composition. The effectiveness of eicosapentaenoic...
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Exposure to a sublethal dose of technical grade flubendiamide hampers angiogenesis in the chicken chorioallantoic membrane
Pesticides are commonly employed to enhance agricultural productivity to meet the demands of the expanding global populace. Their harmful impact on...
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Evaluating Cell Membrane Localization and Intracellular Transport of Proteins by Biotinylation
Protein translocation to the cell membrane and transport through intracellular compartments are dynamic processes frequently altered in cancer cells....
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Emerging role of microbiota derived outer membrane vesicles to preventive, therapeutic and diagnostic proposes
The role of gut microbiota and its products in human health and disease is profoundly investigated. The communication between gut microbiota and the...
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Monitoring yeast regulated cell death: trespassing the point of no return to loss of plasma membrane integrity
Acetic acid and hydrogen peroxide are the most common stimuli to induce apoptosis in yeast. The initial phase of this cell death process is...
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Altered vacuole membrane protein 1 (VMP1) expression is associated with increased NLRP3 inflammasome activation and mitochondrial dysfunction
BackgroundAltered expression of vacuole membrane protein 1 (VMP1) has recently been observed in the context of multiple sclerosis and Parkinson’s...
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Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy
BackgroundOne of the key limitations of targeted cancer therapies is the rapid onset of therapy resistance. Taking BRAF-mutant melanoma as paradigm,...
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Epitope vaccine design for Toxoplasma gondii based on a genome-wide database of membrane proteins
BackgroundThere is presently no effective and safe vaccine for Toxoplasma gondii for humans. The study described here was designed to search for a...
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The vertebrate- and testis- specific transmembrane protein C11ORF94 plays a critical role in sperm-oocyte membrane binding
Sperm-oocyte membrane fusion is necessary for mammalian fertilization. The factors that determine the fusion of sperm with oocytes are largely...
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Micellar Encapsulation of Propofol Reduces its Adsorption on Extracorporeal Membrane Oxygenator (ECMO) Circuit
Extracorporeal membrane oxygenation (ECMO) is a life-saving cardiopulmonary bypass device used on critically ill patients with refractory heart and...
