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Oral probiotics increased the proportion of Treg, Tfr, and Breg cells to inhibit the inflammatory response and impede gestational diabetes mellitus
BackgroundChildren of mothers with gestational diabetes mellitus (GDM) are more prone to acquire type 2 diabetes and obesity as adults. Due to this...
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Using machine learning to identify gene interaction networks associated with breast cancer
BackgroundBreast cancer (BC) is one of the most prevalent cancers worldwide but its etiology remains unclear. Obesity is recognized as a risk factor...
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Evidence for the loss of plasminogen receptor KT gene in chicken
The loss of conserved genes has the potential to alter phenotypes drastically. Screening of vertebrate genomes for lineage-specific gene loss events...
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Structural and functional consequences in the amygdala of leptin-deficient mice
On the one hand, the emotional state can influence food intake and on the other hand, hunger can have an impact on the emotional state. Leptin, which...
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Kisspeptin and the Genetic Obesity Interactome
Background: Kisspeptin (encoded by the KISS1 gene in humans) is an excitatory neuromodulatory peptide implicated in multiple homeostatic systems,...
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Vaspin attenuates steatosis-induced fibrosis via GRP78 receptor by targeting AMPK signaling pathway
Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that is rapidly becoming a public health problem. An imbalance in lipid...
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Glial Endozepines Reverse High-Fat Diet-Induced Obesity by Enhancing Hypothalamic Response to Peripheral Leptin
Research on energy homeostasis has focused on neuronal signaling; however, the role of glial cells has remained little explored. Glial endozepines...
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Orexin A-induced inhibition of leptin expression and secretion in adipocytes reducing plasma leptin levels and hypothalamic leptin resistance
Orexin A (OXA) is a neuropeptide associated with plasma insulin and leptin levels involved in body weight and appetite regulation. However, little is...
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Association of the leptin receptor Q223R (rs1137101) polymorphism with obesity measures in Sri Lankans
ObjectiveThe role of genetic factors in the development of obesity is largely unreported in Sri Lankans. The Q223R (rs1137101) single nucleotide...
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Melanin-Concentrating Hormone, Neuropeptide E-I, and MCH Receptor 1
Melanin-concentrating hormone (MCH) and neuropeptide E-I (NEI) are neuropeptides produced from the pro-melanin-concentrating hormone gene, which are...
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Comparative Study of the Restoring Effect of Metformin, Gonadotropin, and Allosteric Agonist of Luteinizing Hormone Receptor on Spermatogenesis in Male Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus
We compared the effectiveness of human chorionic gonadotropin (hCG; 5 days, 20 IU/rat/day), allosteric luteinizing hormone receptor agonist TP04 (5...
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Hyperleptinemia in obese state renders luminal breast cancers refractory to tamoxifen by coordinating a crosstalk between Med1, miR205 and ErbB
Obese women with hormone receptor-positive breast cancer exhibit poor response to therapy and inferior outcomes. However, the underlying molecular...
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The impact of vitamin D on type 2 diabetes management: boosting PTP1B gene expression and physical activity benefits in rats
BackgroundThe protein tyrosine phosphatase 1B (PTP1B) plays a crucial role in the development of insulin resistance. Aerobic training (AT) and...
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Modulation of rectal cancer stemness, patient outcome and therapy response by adipokines
Response to chemoradiotherapy (CRT) in patients with locally advanced rectal cancer is highly variable. Identification of CRT non-responders and...
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Obesity
In this chapter, we will define obesity as the consequence of excess WAT accumulation that increases the risk of non-communicable diseases. We will...
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Therapeutic potential for P2Y2 receptor antagonism
G protein-coupled receptors are the target of more than 30% of all FDA-approved drug therapies. Though the purinergic P2 receptors have been an...
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Biomarkers in Experimental Diabetes: Studies with Syzygium Cumini (L.) and Links with the Sulfonylurea 1 Receptor
Diabetes mellitus (DM) is showing a global rise in its incidence. Pancreatic beta cell dysfunction, insulin resistance, and inflammation contribute...
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MicroRNAs from edible plants reach the human gastrointestinal tract and may act as potential regulators of gene expression
MicroRNAs (miRNAs) are small single-stranded non-coding RNA molecules that regulate gene expression at the post-transcriptional level. A...
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Telmisartan and candesartan promote browning of white adipose tissue and reverse fatty liver changes in high fat diet fed male albino rats
Obesity is a key risk factor for many diseases, as cardiovascular disorders, diabetes, infertility, osteoarthritis, sleep apnea, non-alcoholic fatty...
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Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor A: Biomarkers Potential in Diabetes
Previously, brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) have been studied only in diabetic neuropathy or...