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The Key Role of Magnetic Resonance Imaging in the Detection of Neurodegenerative Diseases-Associated Biomarkers: A Review
Neurodegenerative diseases (NDs), including chronic disease such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and multiple...
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Advances in brain barriers and brain fluids research in 2021: great progress in a time of adversity
This editorial highlights advances in brain barrier and brain fluid research in 2021. It covers research on components of the blood–brain barrier,...
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Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients
Idiopathic normal pressure hydrocephalus (iNPH) is a neuropathology with unknown cause characterised by gait impairment, cognitive decline and...
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The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer’s disease continuum participants
BackgroundGlymphatic dysfunction is a crucial pathway for dementia. Alzheimer’s disease (AD) pathologies co-existing with cerebral small vessel...
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The regulatory roles of motile cilia in CSF circulation and hydrocephalus
BackgroundCerebrospinal fluid (CSF) is an ultra-filtrated colorless brain fluid that circulates within brain spaces like the ventricular cavities,...
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Modeling cerebrospinal fluid dynamics across the entire intracranial space through integration of four-dimensional flow and intravoxel incoherent motion magnetic resonance imaging
BackgroundBidirectional reciprocal motion of cerebrospinal fluid (CSF) was quantified using four-dimensional (4D) flow magnetic resonance imaging...
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Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation
Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the...
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Frontotemporal dementia as a comorbidity to idiopathic normal pressure hydrocephalus (iNPH): a short review of literature and an unusual case
Behavioural variant frontotemporal dementia (bvFTD) and idiopathic normal pressure hydrocephalus (iNPH) are neurodegenerative diseases that can...
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This was the year that was: brain barriers and brain fluid research in 2019
This editorial highlights advances in brain barrier and brain fluid research published in 2019, as well as addressing current controversies and...
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LRG1: an emerging player in disease pathogenesis
The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a key player in pathogenic ocular neovascularization almost a...
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Long-Term High-Fat Diet Impairs AQP4-Mediated Glymphatic Clearance of Amyloid Beta
As a risk factor for Alzheimer’s disease (AD), studies have demonstrated that long-term high-fat diet (HFD) could accelerate the deposition of...
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Can pulsatile CSF flow across the cerebral aqueduct cause ventriculomegaly? A prospective study of patients with communicating hydrocephalus
BackgroundCommunicating hydrocephalus is a disease where the cerebral ventricles are enlarged. It is characterized by the absence of detectable...
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AQP4 Endocytosis-Lysosome Degradation Mediated by MMP-9/β-DG Involved in Diabetes Cognitive Impairment
Cognitive impairment is considered to be one of the important comorbidities of diabetes, but the underlying mechanisms are widely unknown....
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Comparative analysis of cerebrospinal fluid metabolites in Alzheimer’s disease and idiopathic normal pressure hydrocephalus in a Japanese cohort
BackgroundAlzheimer’s disease (AD) is a most common dementia in elderly people. Since AD symptoms resemble those of other neurodegenerative diseases,...
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Hydrocephalus
Hydrocephalus is an extremely frequent condition either as a disease entity on its own or as a complication or sequelae to other brain diseases. The...
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Comprehensive framework between environment and genomic stability: the open symposium of the Japanese Environmental Mutagen Society (JEMS) in 2019
The open symposium of the Japanese Environmental Mutagen Society (JEMS), under the title of “Comprehensive framework between environment and genomic...
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Neuroimage-Based Consciousness Evaluation of Patients with Secondary Doubtful Hydrocephalus Before and After Lumbar Drainage
Hydrocephalus is often treated with a cerebrospinal fluid shunt (CFS) for excessive amounts of cerebrospinal fluid in the brain. However, it is very...
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Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches
BackgroundThe immune cell compartment of the mammalian brain changes dramatically and peripheral T cells infiltrate the brain parenchyma during...
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Anti-AQP4 autoantibodies promote ATP release from astrocytes and induce mechanical pain in rats
BackgroundIntractable neuropathic pain is a common symptom of neuromyelitis optica spectrum disorder (NMOSD). However, the underlying mechanism of...
