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A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we...
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The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia
BackgroundCD33 is genetically linked to Alzheimer’s disease (AD) susceptibility through differential expression of isoforms in microglia. The role of...
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p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function
Alzheimer’s disease (AD) and other tauopathies are histopathologically characterized by tau aggregation, along with a chronic inflammatory response...
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Phagocytosis and activation of bone marrow‐derived macrophages by Plasmodium falciparum gametocytes
BackgroundThe innate immune response against various life cycle stages of the malaria parasite plays an important role in protection against the...
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Age-related neuroimmune signatures in dorsal root ganglia of a Fabry disease mouse model
Pain in Fabry disease (FD) is generally accepted to result from neuronal damage in the peripheral nervous system as a consequence of excess lipid...
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SETD3 Downregulation Mediates PTEN Upregulation-Induced Ischemic Neuronal Death Through Suppression of Actin Polymerization and Mitochondrial Function
SET domain protein 3 (SETD3) is an actin-specific methyltransferase, a rare post-translational modification with limited known biological functions....
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Caveolin-1 is involved in encephalomyocarditis virus replication in BHK-21 cells
BackgroundEncephalomyocarditis virus, member of Cardiovirus genus within Picornaviridae family, is an important pathogen that infects different...
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Novel Self-Assembled Micelles With Increased Tumor Penetration and Anti-Tumor Efficiency Against Breast Cancer
PurposeRecently, docetaxel (DTX) micelles based on retinoic acid derivative surfactants showed lower systemic toxicity and bioequivalence to...
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Molecular Mechanisms Underlying Synaptic Tagging and Consolidation
After a synapse undergoes long-term potentiation (LTP), it acquires a newly remodeled molecular and structural organization. This reorganization over...
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Identifying CCR5 coreceptor populations permissive for HIV-1 entry and productive infection: implications for in vivo studies
BackgroundThe chemokine receptor CCR5 is the major coreceptor for HIV-1 cell entry. We previously observed that not all CCR5 mAbs reduce HIV-1...
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LPS-squalene interaction on d-galactose intestinal absorption
The dynamic and complex interactions between enteric pathogens and the intestinal epithelium often lead to disturbances in the intestinal barrier,...
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Cell Biology of the Life Cycle of Giardia intestinalis
Giardia intestinalis (G. lamblia, G. duodenalis) is the agent of Giardiasis, a disease widely prevalent throughout the world. It has a life cycle...
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GPR84 regulates pulmonary inflammation by modulating neutrophil functions
Acute lung injury (ALI) is an acute, progressive hypoxic respiratory failure that could develop into acute respiratory distress syndrome (ARDS) with...
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Involvement of Actin Filaments in the Cytotoxic Effect of GD2-Specific Antibodies
Induction of direct cell death is one of the mechanisms of the antitumor effect of GD2-specific antibodies used for the therapy of high-risk...
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Transcellular Transport Behavior of the Intact Polymeric Mixed Micelles with Different Polymeric Ratios
In order to better promote the application of the polymeric mixed micelles (PMMs) in oral delivery, in addition to focusing on the improvement of...
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Micronucleus Assay in Lymphocytes for Human Biomonitoring and Clinical Studies
Micronuclei (MN) are originated when a whole or broken chromosome/chromatin lag at the anaphase of dividing cells and becomes separated from the main...
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Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer’s disease-like mice
BackgroundExposure to sunlight may decrease the risk of develo** Alzheimer’s disease (AD), and visible and near infrared light have been proposed...
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Heparan Sulfate Proteoglycans (HSPGs) Serve as the Mediator Between Monomeric Tau and Its Subsequent Intracellular ERK1/2 Pathway Activation
The conversion of soluble tau protein to insoluble, hyperphosphorylated neurofibrillary tangles (NFTs) is a major hallmark leading to neuronal death...
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DNA methyltransferase 1 deficiency improves macrophage motility and wound healing by ameliorating cholesterol accumulation
Healing of the cutaneous wound requires macrophage recruitment at the sites of injury, where chemotactic migration of macrophages toward the wound is...
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How Does Bioinformatics Play a Role in Fungal Drug Discovery?
Despite all the medical advancements and discoveries over the past several decades, approximately 30% of all known diseases can be currently treated...