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Effect of regulatory cell death on the occurrence and development of head and neck squamous cell carcinoma
Head and neck cancer is a malignant tumour with a high mortality rate characterized by late diagnosis, high recurrence and metastasis rates, and poor...
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The regulation of amino acid metabolism in tumor cell death: from the perspective of physiological functions
Amino acids (AAs) are crucial molecules for the synthesis of mammalian proteins as well as a source of energy and redox equilibrium maintenance. The...
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Drug-induced ER stress leads to induction of programmed cell death pathways of the malaria parasite
The rapid emergence of drug resistance against the mainstream antimalarial drugs has increased the need for development of novel drugs. Recent...
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Biochemical Mechanistic Pathway of Cell Death Induced by Metal-Based Chemotherapeutic Agents
A large plethora of metal complexes that could act as potent anticancer chemotherapeutic agents have been designed and developed in the recent past...
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Cell-Permeable HSP70 Protects Neurons and Astrocytes Against Cell Death in the Rotenone-Induced and Familial Models of Parkinson’s Disease
Heat shock protein 70 (HSP70) is activated under stress response. Its involvement in cell protection, including energy metabolism and quality control...
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Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA
BackgroundAlthough stimulating autophagy caused by UV has been widely demonstrated in skin cells to exert cell protection, it remains unknown the...
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Aryl-functionalised α,α′-Trehalose 6,6′-Glycolipid Induces Mincle-independent Pyroptotic Cell Death
α,α′-Trehalose 6,6′-glycolipids have long been known for their immunostimulatory properties. The adjuvanticity of α,α′-trehalose 6,6′-glycolipids is...
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Cannabinoids induce cell death in leukaemic cells through Parthanatos and PARP-related metabolic disruptions
BackgroundSeveral studies have described a potential anti-tumour effect of cannabinoids (CNB). CNB receptor 2 (CB2) is mostly present in...
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Immunogenic Cell Death-related Signature Evaluates the Tumor Microenvironment and Predicts the Prognosis in Diffuse Large B-Cell Lymphoma
Current literatures suggest a growing body of evidence highlighting the pivotal role of Immunogenic Cell Death (ICD) in multiple tumor types....
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Molecular mechanisms of cell death in bronchopulmonary dysplasia
Bronchopulmonary dysplasia (BPD) in neonates is the most common pulmonary disease that causes neonatal mortality, has complex pathogenesis, and lacks...
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Inflammatory cell death PANoptosis is induced by the anti-cancer curaxin CBL0137 via eliciting the assembly of ZBP1-associated PANoptosome
ObjectivePANoptosis, a new form of regulated cell death, concomitantly manifests hallmarks for pyroptosis, apoptosis, and necroptosis. It has been...
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A novel TCGA-validated programmed cell-death-related signature of ovarian cancer
BackgroundOvarian cancer (OC) is a gynecological malignancy tumor with high recurrence and mortality rates. Programmed cell death (PCD) is an...
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Regulated Cell Death of Retinal Ganglion Cells in Glaucoma: Molecular Insights and Therapeutic Potentials
Glaucoma is a group of diseases characterized by the degeneration of retinal ganglion cells (RGCs) and progressive, irreversible vision loss. High...
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Role of the complement system in kidney cell death induced by Loxosceles venom Sphingomyelinases D
Envenomation by Loxosceles spiders can result in local and systemic pathologies. Systemic loxoscelism, which can lead to death, is characterized by...
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Assessment of Neuronal Cell Death in Caenorhabditis elegans
The nematode Caenorhabditis elegans is a powerful experimental platform for cell biology studies. The molecular mechanisms that mediate cell death...
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The microtubule targeting agent ST-401 triggers cell death in interphase and prevents the formation of polyploid giant cancer cells
Microtubule targeting agents (MTAs) are commonly prescribed to treat cancers and predominantly kill cancer cells in mitosis. Significantly, some...
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In situ chemoimmunotherapy hydrogel elicits immunogenic cell death and evokes efficient antitumor immune response
BackgroundChemoimmunotherapy has shown promising advantages of eliciting immunogenic cell death and activating anti-tumor immune responses. However,...
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Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma
The majority of blood malignancies is incurable and has unforeseeable remitting-relapsing paths in response to different treatments. Cynaropicrin, a...
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Luteolin Protects Against 6-Hydoroxydopamine-Induced Cell Death via an Upregulation of HRD1 and SEL1L
Parkinson’s Disease (PD) is caused by many factors and endoplasmic reticulum (ER) stress is considered as one of the responsible factors for it. ER...
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Mechanisms of metabolic stress induced cell death of human oligodendrocytes: relevance for progressive multiple sclerosis
Oligodendrocyte (OL) injury and loss are central features of evolving lesions in multiple sclerosis. Potential causative mechanisms of OL loss...
