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Methotrexate is associated with decreased total thyroxine in patients with rheumatoid arthritis
BackgroundRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by joint swelling, pain, and deformation. RA patients...
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Decoding Behcet’s Uveitis: an In-depth review of pathogenesis and therapeutic advances
Behcet’s disease (BD) is a rare but globally distributed vasculitis that primarily affects populations in the Mediterranean and Asian regions....
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Sjögren’s syndrome
Sjögren’s syndrome (SS) is characterised as keratoconjunctivitis sicca (dry eyes), xerostomia (dry mouth) commonly associated with salivary gland...
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Spinal P2X4 Receptors Involved in Visceral Hypersensitivity of Neonatal Maternal Separation Rats
Recent studies have demonstrated the vital role of P2X4 receptors (a family of ATP-gated non-selective cation channels) in the transmission of...
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Diagnosis and Management of Immune-Related Adverse Events of Immune Checkpoint Inhibitor Therapy
The landscape of cancer therapy has undergone a profound transformation in the last decade, shifting from traditional cytotoxic chemotherapy to the... -
Autoimmune Diseases Associated with Chikungunya Infection
Chikungunya virus infection (CKV) is an arbovirosis transmitted by Aedes aegypti and Aedes albopictus mosquito. It is now an established infection in... -
The decreased of peripheral blood natural killer cell is associated with serum IL-2 level in the renal tubular acidosis in patients with primary sjogren’s syndrome
BackgroundPrimary Sjogren’s Syndrome (pSS) is a lymphoproliferative disease with autoimmune characteristics, which is characterized by lymphocyte...
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Letter S
Sabin vaccine(polio vaccine; see also Salk vaccine) Although Jonas Salk introduced the first polio vaccines in 1953, another scientist in the US,... -
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Autoimmunerkrankungen
Autoimmunerkrankungen der Haut (AISD) bei Katzen sind sehr selten und machen weniger als 2 % aller Hauterkrankungen aus, bei denen Katzen von... -
m6A methyltransferase METTL3 programs CD4+ T-cell activation and effector T-cell differentiation in systemic lupus erythematosus
BackgroundSystemic lupus erythematosus (SLE) is an autoimmune disorder in which excessive CD4 + T-cell activation and imbalanced effector T-cell...
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Autoimmune PaneLs as PrEdictors of Toxicity in Patients TReated with Immune Checkpoint InhibiTors (ALERT)
BackgroundImmune-checkpoint inhibitors (ICI) can lead to immune-related adverse events (irAEs) in a significant proportion of patients. The...
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Concomitant Polymyalgia Rheumatica and Giant Cell Arteritis Associated with Cystic Echinococcosis: A Rare Geriatric Case
IntroductionParasitic infections could be an important triggering factor for autoimmune diseases. We present a clinical case of concomitant...
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HOXA11-OS participates in lupus nephritis by targeting miR-124-3p mediating Cyr61 to regulate podocyte autophagy
BackgroundThe long chain non-coding RNA HOXA11-OS was recently identified. Increasing studies have shown that HOXA11-OS has regulatory effects on...
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Juvenile dermatomyositis associated with autoantibodies to small ubiquitin-like modifier activating enzyme: a report of 4 cases from North India and a review of literature
BackgroundJuvenile dermatomyositis (JDM) is the commonest inflammatory myositis in children. The clinical phenotype is often characterized by the...
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Predictors of Treatment Change Among Patients with Rheumatoid Arthritis Treated with TNF Inhibitors as First-Line Biologic Agent in the USA: A Cohort Study from Longitudinal Electronic Health Records
BackgroundPrevious observational studies utilizing administrative claims data have largely been unable to consider clinical factors that may be...
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Antidepressant effects of novel positive allosteric modulators of Trk-receptor mediated signaling – a potential therapeutic concept?
BackgroundMajor depressive disorder (MDD) is defined as a complex mental disorder which is characterized by a pervasive low mood and aversion to...
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Regulation of inflammation by VEGF/BDNF signaling in mouse retinal Müller glial cells exposed to high glucose
The inflammatory changes seem to play an important role in the development of diabetic retinopathy (DR). Anti-VEGF therapy has been testified to...