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Central autonomic network dysfunction and plasma Alzheimer’s disease biomarkers in older adults
BackgroundHigher order regulation of autonomic function is maintained by the coordinated activity of specific cortical and subcortical brain regions,...
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Can adults with developmental dyslexia apply statistical knowledge to a new context?
We investigated transfer of artificial grammar learning in adults with and without dyslexia in 3 experiments. In Experiment 1, participants...
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Explaining the influence of practice on the grooved pegboard times of older adults: role of force steadiness
The purpose was to identify the variables that can explain the variance in the grooved pegboard times of older adults categorized as either fast or...
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Long-term Tai Chi training reduces the fusion illusion in older adults
Sound-induced flash illusion (SiFI) is an auditory-dominated audiovisual integration phenomenon that can be used as a reliable indicator of...
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Assessing Dose-Exposure–Response Relationships of Miltefosine in Adults and Children using Physiologically-Based Pharmacokinetic Modeling Approach
ObjectivesMiltefosine is the first and only oral medication to be successfully utilized as an antileishmanial agent. However, the drug is associated...
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Osteomyelitis caused by Streptococcus intermedius in immunocompetent adults — a case report and systematic literature review
Hematogenous osteomyelitis caused by Streptococcus intermedius is rare, particularly in immunocompetent adults. The aim of this paper is to provide...
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Circulating MiRNAs Are Associated With Low-grade Systemic Inflammation and Leptin Levels in Older Adults
Inflammaging refers to the low-grade systemic inflammation that occurs with aging present in chronic non-communicable diseases. MicroRNAs (miRNAs)...
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Methamphetamine alters nucleus accumbens neural activation to monetary loss in healthy young adults
RationaleStimulant drugs like methamphetamine (MA) activate brain reward circuitry, which is linked to the development of problematic drug use. It is...
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Healthy adults favor stable left/right hand choices over performance at an unconstrained reach-to-grasp task
Reach-to-grasp actions are fundamental to the daily activities of human life, but few methods exist to assess individuals’ reaching and gras**...
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Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults
Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However,...
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Insomnia complaints correlated with higher risk of cognitive impairment in older adults following stroke: a National Representative Comparison Study
Although associations among insomnia, cognitive impairment, and stroke have been demonstrated, whether insomnia increases the risk of cognitive...
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Fall risk classification with posturographic parameters in community-dwelling older adults: a machine learning and explainable artificial intelligence approach
BackgroundComputerized posturography obtained in standing conditions has been applied to classify fall risk for older adults or disease groups....
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Integrated cognitive and physical fitness training enhances attention abilities in older adults
Preserving attention abilities is of great concern to older adults who are motivated to maintain their quality of life. Both cognitive and physical...
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Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults
BackgroundImmune responses to COVID-19 mRNA vaccines have not been well characterized in frail older adults. We postulated that frailty is associated...
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Limited training and transfer effects in older and young adults who participated in 12 sessions of process-based working memory training. A three-armed pretest-posttest design study
ObjectiveNumerous studies confirm the effectiveness of cognitive training in older adults. However, there is limited evidence of the transfer...
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Inter-day reliability of heart rate complexity and variability metrics in healthy highly active younger and older adults
PurposeTo investigate the inter-day reliability of time-domain, frequency-domain, and nonlinear HRV metrics in healthy highly active younger and...
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Determinants of COVID-19 vaccination status and hesitancy among older adults in China
Vaccination is the primary defense against severe acute respiratory syndrome coronavirus 2, especially among older adults and those with chronic...
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Characterization of B-cell and T-cell responses to a tetravalent dengue purified inactivated vaccine in healthy adults
The increasing global impact of dengue underscores the need for a dengue virus (DENV) vaccine. We assessed B-cell and T-cell responses following...
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Integrated Exposure–Response of Dupilumab in Children, Adolescents, and Adults With Atopic Dermatitis Using Categorical and Continuous Efficacy Assessments: A Population Analysis
BackgroundWhile the majority of patients with atopic dermatitis (AD) achieve disease control with dupilumab treatment, there is variability in which...
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Two-week step-reduction has limited negative effects on physical function and metabolic health in older adults
PurposeThis study determined the effects of a 2-week step-reduction period followed by 4-week exercise rehabilitation on physical function, body...