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Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates
Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, effective vaccines are...
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Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19
Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are being deployed, but the global need greatly exceeds the supply, and...
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Nonviral Platform for Expression of Recombinant Protein in Insect Cells
Nonviral transfection has been used to express various recombinant proteins, therapeutics, and virus-like particles (VLP) in mammalian and insect...
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Generation and immunogenicity assessment of ELPylated virus-like particles of porcine circovirus type 2
BackgroundPorcine circovirus type 2 (PCV2) is an economically important pathogen affecting swine industry worldwide. The production of current PCV2...
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Epitope-coated polymer particles elicit neutralising antibodies against Plasmodium falciparum sporozoites
The current Malaria RTS,S vaccine is based on virus-like particles (VLPs) comprising the NANP repetitive epitopes from the cicumsporozoite protein...
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Understanding the Phagocytosis of Particles: the Key for Rational Design of Vaccines and Therapeutics
A robust comprehension of phagocytosis is crucial for understanding its importance in innate immunity. A detailed description of the molecular...
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Influenza virus-like particle vaccine containing both apical membrane antigen 1 and microneme-associated antigen proteins of Plasmodium berghei confers protection in mice
BackgroundApical membrane antigen 1 (AMA1) and microneme-associated antigen (MIC) of Plasmodium parasites are important factors involved in host...
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Molecular basis for potent B cell responses to antigen displayed on particles of viral size
Multivalent viral epitopes induce rapid, robust and T cell-independent humoral immune responses, but the biochemical basis for such potency remains...
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Immunization with virus-like particles conjugated to CIDRα1 domain of Plasmodium falciparum erythrocyte membrane protein 1 induces inhibitory antibodies
BackgroundDuring the erythrocytic cycle, Plasmodium falciparum malaria parasites express P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) that...
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Discovery of four new B-cell protective epitopes for malaria using Q beta virus-like particle as platform
Malaria remains one of the world’s most urgent global health problems, with almost half a million deaths and hundreds of millions of clinical cases...
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Construction of Higher-Order VLP-Based Materials and Their Effect on Diffusion and Partitioning
In spite of their role as harmful infectious entities, viruses have gained a significant research attention as they can be exploited as nanomaterials...
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Application of NMR Spectroscopy in Viral Assembly Characterization
Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful technique widely utilized for small molecule and biomolecule characterization in both...
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Histopathological Analysis of Brains from Dogs Infected with Canine Distemper Virus
We describe the use of conventional histology and immunohistochemistry against canine distemper virus (CDV) to examine the brains of domestic dogs...
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The envelope protein of Zika virus interacts with apolipoprotein E early in the infectious cycle and this interaction is conserved on the secreted viral particles
BackgroundZika virus (ZIKV), a member of the Flaviviridae family, has caused massive outbreaks of infection in tropical areas over the last decade...
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Intranasal immunization with coxsackievirus A16 virus-like particles confers protection against lethal infection in neonatal mice
Coxsackievirus A16 (CV-A16) is one of the main causative agents of hand, foot and mouth disease (HFMD) in young children and has become prevalent in...
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Pseudotyped Virus for Flaviviridae
Members of Flaviviridae are enveloped single positive-stranded RNA viruses including hepacivirus, pestivirus, pegivirus, and mosquito-transmitted...
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Quantification of Receptor Association, Dissociation, and NA-Dependent Motility of Influenza A Particles by Biolayer Interferometry
We describe a method for real-time analysis and quantification of influenza A virus (IAV)–receptor interactions by biolayer interferometry (BLI)....
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Adaptive Laboratory Evolution to Improve Recombinant Protein Production Using Insect Cells
Adaptive laboratory evolution (ALE) is a powerful tool for enhancing the fitness of cell lines in specific applications, including recombinant...
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Assembly of tomato blistering mosaic virus-like particles using a baculovirus expression vector system
The expression of several structural proteins from a wide variety of viruses in heterologous cell culture systems results in the formation of...
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Creating Artificial Viruses Using Self-assembled Proteins and Polypeptides
Viruses are extraordinary entities that have inspired biomolecular engineers to craft artificial versions of them. Recently, multiple efforts have...