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Metabolically Generated Stable Isotope for Identification of DNA N6-Methyladenine Origin in Cultured Mammalian Cells
DNA N6-methyladenine (6mA) is a prevalent epigenetic modification in prokaryotes and protists and a potential epigenetic marker in invertebrates,...
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Intersectional monosynaptic tracing for dissecting subtype-specific organization of GABAergic interneuron inputs
Functionally and anatomically distinct cortical substructures, such as areas or layers, contain different principal neuron (PN) subtypes that...
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Lineage plasticity enables low-ER luminal tumors to evolve and gain basal-like traits
Stratifying breast cancer into specific molecular or histologic subtypes aids in therapeutic decision-making and predicting outcomes; however, these...
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COVID-19 patient and personal safety – lessons learnt for pandemic preparedness and the way to the next normal
BackgroundThe COVID-19 pandemic has profoundly challenged societies and healthcare systems in particular. To prevent the spread of SARS-CoV-2,...
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Modelling Cortical Laminar Connectivity in the Macaque Brain
In 1991, Felleman and Van Essen published their seminal study regarding hierarchical processing in the primate cerebral cortex. Their work...
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Rapid screening and identification of viral pathogens in metagenomic data
BackgroundVirus screening and viral genome reconstruction are urgent and crucial for the rapid identification of viral pathogens, i.e., tracing the...
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Rabies Virus Pseudotyped with CVS-N2C Glycoprotein as a Powerful Tool for Retrograde Neuronal Network Tracing
Efficient viral vectors for map** and manipulating long-projection neuronal circuits are crucial in structural and functional studies of the brain....
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Novel animal model of soft tissue tumor due to aberrant hedgehog signaling activation in pericyte lineage
Pericytes are pluripotent cells that enclose the endothelium of small blood vessels in the whole body. These cells are thought to play a limited role...
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Deep Learning in Educational Scenario
The relationship between deep learning and human neural networks is speculative due to limited understanding of brain processes. Deep Learning...
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Acetyl-CoA synthetase 2 contributes to a better prognosis for liver cancer by switching acetate-glucose metabolism
Acetyl-CoA synthetase 2 (ACSS2)-dependent acetate usage has generally been associated with tumorigenesis and increased malignancy in cancers under...
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Neocortical circuits in pain and pain relief
The sensory, associative and limbic neocortical structures play a critical role in sha** incoming noxious inputs to generate variable pain...
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Evaluation of a Wearable AR Platform for Guiding Complex Craniotomies in Neurosurgery
Today, neuronavigation is widely used in daily clinical routine to perform safe and efficient surgery. Augmented reality (AR) interfaces can provide...
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Converting sounds to meaning with ventral semantic language networks: integration of interdisciplinary data on brain connectivity, direct electrical stimulation and clinical disconnection syndromes
Numerous traditional linguistic theories propose that semantic language pathways convert sounds to meaningful concepts, generating interpretations...
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Subclonal heterogeneity and evolution in breast cancer
Subclonal heterogeneity and evolution are characteristics of breast cancer that play a fundamental role in tumour development, progression and...
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Y-SNP Haplogroup Hierarchy Finder: a web tool for Y-SNP haplogroup assignment
The application of massively parallel sequencing (MPS) data from whole genomes has allowed very many more Y-SNP loci to be genotyped simultaneously...
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Excitatory Crossmodal Input to a Widespread Population of Primary Sensory Cortical Neurons
Crossmodal information processing in sensory cortices has been reported in sparsely distributed neurons under normal conditions and can undergo...
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Bioinformatics for the Origin and Evolution of Viruses
The ongoing pandemic of coronavirus disease 2019 (COVID19) caused by infection with human SARS-CoV-2 is a global threat to the human population....
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Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development
The immunological mechanisms underlying chronic colitis are poorly understood. T follicular helper (T FH ) cells are critical in hel** B cells during...
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Acetyl-CoA metabolism in cancer
Few metabolites can claim a more central and versatile role in cell metabolism than acetyl coenzyme A (acetyl-CoA). Acetyl-CoA is produced during...
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A full genome tiling array enhanced the inspection and quarantine of SARS-CoV-2
As the worldwide spreading epidemic of SARS-CoV-2, quick inspection and quarantine of passengers for SARS-CoV-2 infection are essential for...
