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Modulatory Processes in Craniofacial Pain States
Pain is a common symptom associated with many disorders affecting the craniofacial tissues that include the teeth and their supporting structures,...
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Interleukin-6: evolving role in the management of neuropathic pain in neuroimmunological disorders
BackgroundNeuropathic pain in neuroimmunological disorders refers to pain caused by a lesion or disease of the somatosensory system such as multiple...
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Mechanisms of ATP release in pain: role of pannexin and connexin channels
Pain is a physiological response to bodily damage and serves as a warning of potential threat. Pain can also transform from an acute response to...
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Peptide Mimetic of BDNF Loop 4 Blocks Behavioral Signs of Morphine Withdrawal Syndrome and Prevents the Increase in ΔFosB Level in the Striatum of Rats
Activity of compound GSB-106, a low-molecular mimetic of loop 4 of the brain neurotrophic factor (BDNF), was studied in experimental morphine...
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Activation of P2X4 receptors in midbrain cerebrospinal fluid-contacting nucleus leads to mechanical hyperalgesia in chronic constriction injury rats
Neuropathic pain is a refractory pain state, and its mechanism is still not clear. Previous studies have shown that the purine receptor P2X4R...
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Alternative Therapies for Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect caused by many antineoplastic drugs. Currently, there are no FDA-approved...
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Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy
In the spinal cord, attenuation of the inhibitory action of glycine is related to an increase in both inflammatory and diabetic neuropathic pain;...
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Comparative Efficacy of GABAA and GABAB Receptor Agonists in Pain Alleviation in a Spinal Cord Injury Model of Neuropathic Pain
We investigated the effectiveness of intrathecal introduction of GABA A and GABA B receptor agonists in reversing pain modalities in a central model of...
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Mirror-Image Pain Update: Complex Interactions Between Central and Peripheral Mechanisms
The appearance of contralateral effects after unilateral injury has been shown in various experimental pain models, as well as in clinics. They...
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Botulinum Toxin Therapy for Neuropathic Pain (NP)
Neuropathic pain (NP) arises from irritation or damage of nociceptive nerve fibers or nociceptive neurons. It is a common form of pain, often poorly...
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Expression in skin biopsies supports genetic evidence linking CAMKK2, P2X7R and P2X4R with HIV-associated sensory neuropathy
HIV-associated sensory neuropathy (HIV-SN) affects 14–38% of HIV+ individuals stable on therapy with no neurotoxic drugs. Polymorphisms in CAMKK2 , P2X7R...
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Models of Diabetes in Rats: A Focus on Diabetic Neuropathy and Biomarkers
The increased prevalence of diabetic neuropathy (DN), as reported by World Health Organization, is seriously alarming. There is an unmet need to...
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This is also known as subjective time expansion. The term tachypsychia comes from the Greek words tachos (swiftness) and psuchè (life breath, spirit,...
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A
Abdominal aura is also known as visceral aura and epigastric aura. The term abdominal aura is indebted to the Latin words abdomen (belly) and aura...
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Anxiolytic effects of the novel α2δ ligand mirogabalin in a rat model of chronic constriction injury, an experimental model of neuropathic pain
RationalePsychiatric disorders such as anxiety and depression are frequently observed in neuropathic pain patients, and negatively impact their...
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Anti-inflammatory potential of liraglutide, a glucagon-like peptide-1 receptor agonist, in rats with peripheral acute inflammation
The present study aimed to explore the possible anti-inflammatory actions of liraglutide (LRG), a glucagon-like peptide-1 (GLP-1) receptor agonist,...
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Recurrent antinociception induced by intrathecal or peripheral oxytocin in a neuropathic pain rat model
The search for new ligands to treat neuropathic pain remains a challenge. Recently, oxytocin has emerged as an interesting molecule modulating...
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Cannabinoids: an Effective Treatment for Chemotherapy-Induced Peripheral Neurotoxicity?
Chemotherapy-induced peripheral neurotoxicity (CIPN) is one of the most frequent side effects of antineoplastic treatment, particularly of lung,...
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Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain
Neuropathic pain is a chronic condition triggered by lesions to the somatosensory nervous system in which pain stimuli occur spontaneously or as...
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The Role of Inflammation in the Development of Diabetic Polyneuropathy and the Potential for Its Correction
Objectives. To study the efficacy of the drug Cytoflavin in patients with diabetic polyneuropathy (DPN) by assessing the blood tumor necrosis...