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Suppression of cytokine release syndrome during CAR-T-cell therapy via a subcutaneously injected interleukin-6-adsorbing hydrogel
The infusion of chimaeric antigen receptor (CAR) T cells can trigger the release of life-threatening supraphysiological levels of pro-inflammatory...
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Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies
T cells are fundamental components in tumour immunity and cancer immunotherapies, which have made immense strides and revolutionized cancer treatment...
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CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models
BackgroundRhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood, whose prognosis is still poor especially for metastatic,...
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Enhancing CAR-T cells: unleashing lasting impact potential with phytohemagglutinin activation in in vivo leukemia model
Chimeric antigen receptor T (CAR-T) cell therapy holds great promise as an innovative immunotherapeutic approach for cancer treatment. To optimize...
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ThermomiR-377-3p-induced suppression of Cirbp expression is required for effective elimination of cancer cells and cancer stem-like cells by hyperthermia
BackgroundIn recent years, the development of adjunctive therapeutic hyperthermia for cancer therapy has received considerable attention. However,...
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Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria
The steady flow of lactic acid (LA) from tumor cells to the extracellular space via the monocarboxylate transporter symport system suppresses...
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A therapeutic hepatitis B mRNA vaccine with strong immunogenicity and persistent virological suppression
Here we report on the development and comprehensive evaluations of an mRNA vaccine for chronic hepatitis B (CHB) treatment. In two different HBV...
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Antitumor progenitor exhausted CD8+ T cells are sustained by TCR engagement
The durability of an antitumor immune response is mediated in part by the persistence of progenitor exhausted CD8 + T cells (Tpex). Tpex serve as a...
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Regulatory T cells in the face of the intestinal microbiota
Regulatory T cells (T reg cells) are key players in ensuring a peaceful coexistence with microorganisms and food antigens at intestinal borders....
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Control of the antitumour activity and specificity of CAR T cells via organic adapters covalently tethering the CAR to tumour cells
On-target off-tumour toxicity limits the anticancer applicability of chimaeric antigen receptor (CAR) T cells. Here we show that the tumour-targeting...
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Human T-cell lymphotropic virus type 1 (HTLV-1) grip on T-cells: investigating the viral tapestry of activation
IntroductionHuman T-cell Lymphotropic virus type 1 (HTLV-1) belongs to retroviridae which is connected to two major diseases, including...
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GPC3-targeted CAR-T cells expressing GLUT1 or AGK exhibit enhanced antitumor activity against hepatocellular carcinoma
Chimeric antigen receptor-expressing T (CAR-T) cells induce robust antitumor responses in patients with hematologic malignancies. However, CAR-T...
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Helios expressing regulatory T cells are correlated with decreased IL-2 producing CD8 T cells and antibody diversity in Mozambican individuals living chronically with HIV-1
BackgroundHuman immunodeficiency virus type 1 (HIV-1) causes impairment of T and B cell responses, which begins during the acute phase of infection...
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Deciphering the importance of culture pH on CD22 CAR T-cells characteristics
BackgroundChimeric antigen receptor (CAR) T-cells have demonstrated significant efficacy in targeting hematological malignancies, and their use...
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CD20+ T cells: an emerging T cell subset in human pathology
IntroductionAlthough CD20 is classically a B cell marker, in the last three decades, dim expression has been noted on a subset of T cells as well...
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High-Dimensional Single-Cell Profiling of Tumor-Infiltrating CD4+ Regulatory T Cells
CD4+ T regulatory cells (Tregs) are a specialized subset of T lymphocytes, which promote immune homeostasis and tumor immunosuppression by...
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Isolation and Functional Characterization of Regulatory CD4+ T Cells from the Inflamed Joints of Patients with Rheumatoid Arthritis
Regulatory T cellsRegulatory T cells (Tregs) play a critical role in maintaining immune homeostasis and in preventing and controlling unwanted immune...
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Targeted desialylation and cytolysis of tumour cells by fusing a sialidase to a bispecific T-cell engager
Bispecific T-cell engagers (BiTEs) bring together tumour cells and cytotoxic T cells by binding to specific cell-surface tumour antigens and T-cell...
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Dynamics and specificities of T cells in cancer immunotherapy
Recent advances in cancer immunotherapy — ranging from immune-checkpoint blockade therapy to adoptive cellular therapy and vaccines — have...
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Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis
Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of...
