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Glutaminases
Mammalian glutaminases catalyze the stoichiometric conversion of l-glutamine to l-glutamate and ammonium ions. In brain, glutaminase is considered...
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Role of SNTA1 in Rac1 activation, modulation of ROS generation, and migratory potential of human breast cancer cells
Background:Alpha-1-syntrophin (SNTA1) has been implicated in the activation of Rac1. However, the underlying mechanism has not yet been explored....
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Ultrasound-assisted nonviral gene transfer of AQP1 to the irradiated minipig parotid gland restores fluid secretion
Xerostomia is a common side effect of ionizing radiation used to treat head and neck cancer. A groundbreaking Phase I human clinical trial using...
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Time dynamics of protein complexes in the AD11 transgenic mouse model for Alzheimer’s disease like pathology
BackgroundMany approaches exist to integrate protein-protein interaction data with other sources of information, most notably with gene co-expression...
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Role for Protein Kinase CK2 on Cell Proliferation: Assessing CK2 Complex Components in the Nucleus During the Cell Cycle Progression
CK2 is one of the serine threonine kinases known to be essential for basic cell viability and survival. Until recently, genetic, biochemical, and...
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A new look at cerebrospinal fluid circulation
According to the traditional understanding of cerebrospinal fluid (CSF) physiology, the majority of CSF is produced by the choroid plexus, circulates...
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Readaptation of Atrophied Muscle – from Protein Degradation to Synthesis
An important question in both rehabilitation medicine and space flight medicine is that of optimizing recovery processes in atrophied muscle after...
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Cardiac Channelopathies and the Molecular Autopsy
This chapter reviews clinical and molecular observations for three potentially lethal arrhythmia syndromes: long QT syndrome, catecholaminergic...
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Nitric Oxide Signaling and Nitrosative Stress in the Musculoskeletal System
Nitric oxide (NO) is a multifaceted signaling molecule in the musculoskeletal system. In bone, NO can act as a signal molecule and has anabolic...
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Phosphoinositides and PDZ Domain Scaffolds
The discovery that PSD-95/Discs large/ZO-1 (PDZ) domains can function as lipid-binding modules, in particular interacting with phosphoinositides...
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Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland
BackgroundBreast tissue is among the most sensitive tissues to the carcinogenic actions of ionizing radiation and epidemiological studies have linked...
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Calcium Dyshomeostasis in Astrocytes After Ischemia
Astrocytes play significant roles in the demise of brain tissue after cerebral ischemia. Dysfunction in the Ca2+ homeostasis process has the...
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Differential Expression of Genes Involved in the Degeneration and Regeneration Pathways in Mouse Models for Muscular Dystrophies
The genetically determined muscular dystrophies are caused by mutations in genes coding for muscle proteins. Differences in the phenotypes are mainly...
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Research progress on neurobiology of neuronal nitric oxide synthase
Neuronal nitric oxide synthase (nNOS) is mainly expressed in neurons, to some extent in astrocytes and neuronal stem cells. The alternative splicing...
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Bioinformatic analyses identifies novel protein-coding pharmacogenomic markers associated with paclitaxel sensitivity in NCI60 cancer cell lines
BackgroundPaclitaxel is a microtubule-stabilizing drug that has been commonly used in treating cancer. Due to genetic heterogeneity within patient...
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Brain expression of the water channels Aquaporin-1 and -4 in mice with acute liver injury, hyperammonemia and brain edema
Cerebral edema is a feared complication to acute liver failure (ALF), but the pathogenesis is still poorly understood. The water channels Aquaporin-1...
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Eccentric stimulation reveals an involvement of FGF6 in muscle resistance to mechanical stress
The objective of this report was to analyse a potential role for FGF6 in muscle resistance to mechanical stress. Normal or regenerating muscles of...
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Personalizing Risk Assessments and Treatments for Complex Cardiovascular Disease
The term “cardiovascular disease” encompasses a number of different conditions that affect different aspects of the circulatory system. Family...
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Analysis by two-dimensional Blue Native/SDS-PAGE of membrane protein alterations in rat soleus muscle after hindlimb unloading
Muscle atrophy occurring in several pathophysiological conditions determines decreases in muscle protein synthesis, increases in the rate of...
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Genomic risk factors in sudden infant death syndrome
Sudden infant death syndrome (SIDS) is a major contributor to postneonatal infant death, and is the third leading cause of infant mortality in the...