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Biallelic loss of TRAPPC9 function links vesicle trafficking pathway to autosomal recessive intellectual disability
BackgroundThe trafficking protein particle (TRAPP) complex subunit 9 (C9) protein is a member of TRAPP-II complexes and regulates vesicle...
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L-carnitine Modulates Cognitive Impairment Induced by Doxorubicin and Cyclophosphamide in Rats; Insights to Oxidative Stress, Inflammation, Synaptic Plasticity, Liver/brain, and Kidney/brain Axes
Chemotherapy-induced cognitive impairment in cancer patients is known as "chemobrain". Doxorubicin and Cyclophosphamide are two chemotherapeutic...
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Cortical Synaptic Reorganization Under Chronic Arsenic Exposure
There is solid epidemiological evidence that arsenic exposure leads to cognitive impairment, while experimental work supports the hypothesis that it...
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β2-Adrenergic Regulation of the Neuromuscular Transmission and Its Lipid-Dependent Switch
β2-Adrenoceptors (β2-ARs) are the most abundant subtype of adrenergic receptors in skeletal muscles. Their activation via a stabilization of...
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Restoring Synaptic Function: How Intranasal Delivery of 3D-Cultured hUSSC Exosomes Improve Learning and Memory Deficits in Alzheimer’s Disease
Memory problems are often the first signs of cognitive impairment related to Alzheimer’s disease (AD), and stem cells and stem cell-derived exosomes...
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In vivo tau pathology is associated with synaptic loss and altered synaptic function
BackgroundThe mechanism of synaptic loss in Alzheimer’s disease is poorly understood and may be associated with tau pathology. In this combined...
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Upregulated ECM genes and increased synaptic activity in Parkinson’s human DA neurons with PINK1/ PRKN mutations
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. Primary symptoms of PD arise with the loss of dopaminergic (DA)...
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Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor
BackgroundPerioperative neurocognitive disorders (PNDs) are considered the most common postoperative complication in geriatric patients. However, its...
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Dense core vesicle markers in CSF and cortical tissues of patients with Alzheimer’s disease
BackgroundNew fluid biomarkers for Alzheimer's disease (AD) that reveal synaptic and neural network dysfunctions are needed for clinical practice and...
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BMECs Ameliorate High Glucose-Induced Morphological Aberrations and Synaptic Dysfunction via VEGF-Mediated Modulation of Glucose Uptake in Cortical Neurons
It has been demonstrated that diabetes cause neurite degeneration in the brain and cognitive impairment and neurovascular interactions are crucial...
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Regulation of Ryanodine Receptor-Dependent Neurotransmitter Release by AIP, Calstabins, and Presenilins
Ryanodine receptors (RyRs) are Ca2+ release channels located in the endoplasmic reticulum membrane. Presynaptic RyRs play important roles in...
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Neuroligin-3 Regulates Excitatory Synaptic Transmission and EPSP-Spike Coupling in the Dentate Gyrus In Vivo
Neuroligin-3 (Nlgn3), a neuronal adhesion protein implicated in autism spectrum disorder (ASD), is expressed at excitatory and inhibitory...
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Estrogen-related receptor gamma regulates mitochondrial and synaptic genes and modulates vulnerability to synucleinopathy
Many studies implicate mitochondrial dysfunction as a key contributor to cell loss in Parkinson disease (PD). Previous analyses of dopaminergic...
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Death-associated protein kinase 1 as a therapeutic target for Alzheimer's disease
Alzheimer’s disease (AD) is the most prevalent form of dementia in the elderly and represents a major clinical challenge in the ageing society....
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Super-resolution microscopy: a closer look at synaptic dysfunction in Alzheimer disease
The synapse has emerged as a critical neuronal structure in the degenerative process of Alzheimer disease (AD), in which the pathogenic signals of...
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Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance
Social hierarchy is established as an outcome of individual social behaviors, such as dominance behavior during long-term interactions with others....
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Integrated Proteomics and Protein Co-expression Network Analysis Identifies Novel Epileptogenic Mechanism in Mesial Temporal Lobe Epilepsy
Over 50 million people worldwide are affected by epilepsy, a common neurological disorder that has a high rate of drug resistance and diverse...
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Neuronal Protein Farnesylation Regulates Hippocampal Synaptic Plasticity and Cognitive Function
Protein prenylation is a post-translational lipid modification that governs a variety of important cellular signaling pathways, including those...
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SCAMP5 mediates activity-dependent enhancement of NHE6 recruitment to synaptic vesicles during synaptic plasticity
Na + (K + )/H + exchanger 6 (NHE6) on synaptic vesicle (SV) is critical for the presynaptic regulation of quantal size at the glutamatergic synapses by...
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Expanding the genetic and phenotypic spectrum of congenital myasthenic syndrome: new homozygous VAMP1 splicing variants in 2 novel individuals
We report the cases of two Spanish pediatric patients with hypotonia, muscle weakness and feeding difficulties at birth. Whole-exome sequencing (WES)...
