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Genomics, convergent neuroscience and progress in understanding autism spectrum disorder
More than a hundred genes have been identified that, when disrupted, impart large risk for autism spectrum disorder (ASD). Current knowledge about...
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Molecular subtypes based on cuproptosis-related genes and tumor microenvironment infiltration characteristics in pancreatic adenocarcinoma
BackgroundMultiple molecular subtypes with distinct clinical outcomes in pancreatic adenocarcinoma (PAAD) have been identified in recent years....
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Metapangenomics reveals depth-dependent shifts in metabolic potential for the ubiquitous marine bacterial SAR324 lineage
BackgroundOceanic microbiomes play a pivotal role in the global carbon cycle and are central to the transformation and recycling of carbon and energy...
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Rest Tremor
By definition, rest tremor is an involuntary oscillation occurring while the body segment is maintained at rest, fully supported against gravity. To...
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Edaravone Alleviates Traumatic Brain Injury by Inhibition of Ferroptosis via FSP1 Pathway
Traumatic brain injury (TBI) is a highly severe form of trauma with complex series of reactions in brain tissue which ultimately results in neuronal...
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Classification of SARS-CoV-2 viral genome sequences using Neurochaos Learning
AbstractThe high spread rate of SARS-CoV-2 virus has put the researchers all over the world in a demanding situation. The need of the hour is to...
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S4D-ECG: A Shallow State-of-the-Art Model for Cardiac Abnormality Classification
PurposeThis study introduces an algorithm specifically designed for processing unprocessed 12-lead electrocardiogram (ECG) data, with the primary aim...
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APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis
BackgroundCerebral glucose hypometabolism is consistently observed in individuals with Alzheimer’s disease (AD), as well as in young cognitively...
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Astrocytic pathology in Alpers’ syndrome
Refractory epilepsy is the main neurological manifestation of Alpers’ syndrome, a severe childhood-onset mitochondrial disease caused by bi-allelic...
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Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank
Cardiometabolic diseases are the leading cause of death worldwide. Despite a known genetic component, our understanding of these diseases remains...
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Influenza from a One Health Perspective: Infection by a Highly Versatile Virus
Influenza A viruses (IAVs) are among the most versatile viruses, in terms of host range, pathogenesis, route of transmission, transmissibility...
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Inflammation and neuronal gene expression changes differ in early versus late chronic traumatic encephalopathy brain
BackgroundOur understanding of the molecular underpinnings of chronic traumatic encephalopathy (CTE) and its associated pathology in post-mortem...
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Speech and language deficits are central to SETBP1 haploinsufficiency disorder
Expressive communication impairment is associated with haploinsufficiency of SETBP1 , as reported in small case series. Heterozygous pathogenic...
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XGBCDA: a multiple heterogeneous networks-based method for predicting circRNA-disease associations
BackgroundBiological experiments have demonstrated that circRNA plays an essential role in various biological processes and human diseases. However,...
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Aberrant expression of the microtubule-associated protein tau is an independent prognostic feature in prostate cancer
BackgroundMicrotubule-associated protein Tau (MAPT) overexpression has been linked to poor prognosis and decreased response to taxane-based therapies...
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Differential control of respiratory frequency and tidal volume during exercise
The lack of a testable model explaining how ventilation is regulated in different exercise conditions has been repeatedly acknowledged in the field...
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Global effects of identity and aging on the human sperm methylome
BackgroundAs the average age of fatherhood increases worldwide, so too does the need for understanding effects of aging in male germline cells....
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Paleo-Siberian Substrate in the Gene Pool of Koryaks according to Data on Autosomal SNP Polymorphism and Y-Chromosome Haplogroups
Abstract —The gene pool of the Koryaks was studied in comparison with other Far Eastern and Siberian peoples using a genome-wide panel of autosomal...
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Relative versus absolute RNA quantification: a comparative analysis based on the example of endothelial expression of vasoactive receptors
BackgroundIn the present study, two distinct PCR methods were used for the quantification of genetic material and their results were compared:...
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Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus
The prefrontal cortex (PFC) enables mammals to respond to situations, including internal states, with appropriate actions. One such internal state...
