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The Role of Lipidomics in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome commonly diagnosed in early childhood; it is usually characterized by...
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Sphingolipids as Biomarkers of Disease
Despite the advancements in modern medicine, there are still difficulties in diagnosing common illnesses. The invasiveness and price of the tests...
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LC-MS based sphingolipidomic study on A549 human lung adenocarcinoma cell line and its taxol-resistant strain
BackgroundResistance to chemotherapy drugs (e.g. taxol) has been a major obstacle in successful cancer treatment. In A549 human lung adenocarcinoma,...
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Introduction: Enigmas of Sphingolipids
Sphingolipid biology has enjoyed a remarkable rise to fame over the last two decades. Various molecules from this lipid family have been implicated...
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Ceramide Channels
Are ceramide molecules capable of self-assembling in biological and phospholipid membranes to form ceramide channels: membrane channels capable to...
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DEGS1 variant causes neurological disorder
Sphingolipidoses are monogenic lipid storage diseases caused by variants in enzymes of lipid synthesis and metabolism. We describe an autosomal...
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Early central vs. peripheral immunological and neurobiological effects of fingolimod—a longitudinal study
AbstractFingolimod (FTY) is known to have multiple effects on the immune system and the central nervous system (CNS) in patients with multiple...
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Metabolic regulation of lifespan from a C. elegans perspective
Decline of cellular functions especially cognitive is a major deficit that arises with age in humans. Harnessing the strengths of small and genetic...
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The diversity and breadth of cancer cell fatty acid metabolism
Tumor cellular metabolism exhibits distinguishing features that collectively enhance biomass synthesis while maintaining redox balance and cellular...
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Role of Bioactive Sphingolipids in Inflammation and Eye Diseases
Inflammation is a common underlying factor in a diversity of ocular diseases, ranging from macular degeneration, autoimmune uveitis, glaucoma,...
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Role of Sphingolipids in Death Receptor Signalling
Sphingolipids (SLs) are sphingoid base-containing lipids, which are enriched in plasma membrane microdomains. Some SLs behave as bioactive molecules,...
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Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia
AbstractVentilator-associated pneumonia (VAP) is a major cause of morbidity and mortality in critically ill patients. Here, we employed the broad...
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Membrane microdomains regulate NLRP10- and NLRP12-dependent signalling in A549 cells challenged with cigarette smoke extract
Chronic obstructive pulmonary disease (COPD) is predicted to become the third leading cause of death and disability worldwide by 2030; with cigarette...
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Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects
(R,S)-Ketamine produces rapid, robust, and sustained antidepressant effects in major depressive disorder. Specifically, its pharmacological efficacy...
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Increased Plasma Levels of Select Deoxy-ceramide and Ceramide Species are Associated with Increased Odds of Diabetic Neuropathy in Type 1 Diabetes: A Pilot Study
Plasma deoxy-sphingoid bases are elevated in type 2 diabetes patients and correlate with the stage of diabetic distal sensorimotor polyneuropathy;...
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The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration
Bioactive sphingolipids: sphingosine, sphingosine-1-phosphate (S1P), ceramide, and ceramide-1-phosphate (C1P) are increasingly implicated in cell...
