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Characterization of Risk Factors for Modeling of Type 2 Diabetes Mellitus Induced by a High-Fat Diet in C57BL/6 Mice
Type 2 diabetes mellitus develops due to a combination of genetic and environmental factors. C57BL/6 mice prone to obesity and leptin resistance were...
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Long-term PM2.5 exposure disrupts corneal epithelial homeostasis by impairing limbal stem/progenitor cells in humans and rat models
BackgroundLimbal stem/progenitor cells (LSPCs) play a crucial role in maintaining corneal health by regulating epithelial homeostasis. Although PM2.5...
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A single all-out bout of 30-s sprint-cycle performed on 5 consecutive days per week over 6 weeks does not enhance cardiovascular fitness, maximal strength, and clinical health markers in physically active young adults
BackgroundThis study examined the effects of a single all-out bout of 30-s sprint-cycle performed daily for 5 consecutive days per week for 6 weeks,...
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Obesity, cancer risk, and time-restricted eating
Obesity and the associated metabolic syndrome is considered a pandemic whose prevalence is steadily increasing in many countries worldwide. It is a...
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Lifestyle intervention program reduces metabolic syndrome in a high-risk population
ObjectiveThe purpose of this study is to demonstrate the effectiveness of a short-term faith-based lifestyle intervention that reduced risk factors...
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Effect of electromyostimulation training on intramuscular fat accumulation determined by ultrasonography in older adults
PurposeElectromyostimulation (EMS) induces a short-term change in muscle metabolism, and EMS training induces long-term improvements of muscle...
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Effect of low-volume combined aerobic and resistance high-intensity interval training on vascular health in people with type 2 diabetes: a randomised controlled trial
PurposeWe compared the effects of low-volume combined aerobic and resistance high-intensity interval training (C-HIIT), combined moderate-intensity...
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The antigen CD300e drives T cell inflammation in adipose tissue and elicits an antibody response predictive of the insulin sensitivity recovery in obese patients
Obesity and insulin resistance (IR), the key features of metabolic syndrome, are closely associated with a state of chronic, low-grade inflammation....
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Preoperative hypokalemia can increase complications after colorectal cancer surgery: a propensity score matching analysis
BackgroundWhether hypokalemia can affect the short-term outcomes of CRC patients after radical surgery remains unclear. The purpose of this study was...
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Metabolic Pathways and Cell Signaling
This chapter overviews the basic features of metabolic pathways concerning the three main classes of energetic substrates – carbohydrates, lipids and...
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Influence of pre-operative oral carbohydrate loading vs. standard fasting on tumor proliferation and clinical outcome in breast cancer patients ─ a randomized trial
BackgroundConflicting results have been reported on the influence of carbohydrates in breast cancer.
ObjectiveTo determine the influence of...
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Recurrent circadian fasting (RCF) improves blood pressure, biomarkers of cardiometabolic risk and regulates inflammation in men
BackgroundThe effects of fasting on health in non-human models have been widely publicised for a long time and emerging evidence support the idea...
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The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction
Diabetes-associated cognitive dysfunction is linked to chronic hyperglycemia, oxidative stress, inflammation, cholinergic dysfunction, and neuronal...
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The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population
BackgroundBioactive lipids produced by human cells or by the gut microbiota might play an important role in health and disease. Dietary intakes are...
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Effects of rosuvastatin on serum glucose and insulin in hyperuricemic rats
BackgroundHyperuricemia is a state in which the serum levels of uric acid (UA) are elevated. This study was to determine the roles of rosuvastatin in...
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Nutritional Status Differentially Alters Cytochrome P450 3A4 (CYP3A4) and Uridine 5′-Diphospho-Glucuronosyltransferase (UGT) Mediated Drug Metabolism: Effect of Short-Term Fasting and High Fat Diet on Midazolam Metabolism
Background and ObjectivesPrevious studies have shown that nutritional status can alter drug metabolism which may result in treatment failure or...
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Salsalate: a pleotropic anti-inflammatory drug in the treatment of diabetes, obesity, and metabolic diseases
Type two Diabetes Mellitus (T2DM) is a rising epidemic. Available therapeutic strategies have provided glycaemic control via HbA1c reduction but fail...
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Physically active men present a healthier cardiometabolic profile in response to a balanced meal compared to inactive men
PurposePost-meal cardiometabolic responses are critical for health, and may be influenced by physical activity. The objective of this study was to...
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Association between admission plasma 2-oxoglutarate levels and short-term outcomes in patients with acute heart failure: a prospective cohort study
Background2-oxoglutarate (2OG), an intermediate metabolite in the tricarboxylic acid cycle, has been found to associate with chronic heart failure...
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Understanding how educational interventions improve treatment adherence in patients with familial hypercholesterolaemia: a systematic review
Effective treatments for familial hypercholesterolaemia (FH) offer patients the opportunity of normal life expectancy, but lifelong adherence to both...
