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Physical Exercise as Intervention in Parkinsonism
Physical exercise, particularly for individuals with sedentary occupations and independent of activity type, offers probably the most effective...
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Acute behavioural effects of bupropion and naltrexone, alone and in combination, in non-deprived male rats presented with palatable mash
RationaleIn appetite research, drugs frequently progress to clinical trials on the basis of outcome (reduced food intake/body weight gain) with...
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Regulation of immunological balance by sustained interferon-γ gene transfer for acute phase of atopic dermatitis in mice
Interferon (IFN)-γ, a potent T helper 1 (Th1) cell cytokine, is suggested to suppress Th2 cell responses. Here, we aimed to investigate whether...
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Genetic marking and characterization of Tac2-expressing neurons in the central and peripheral nervous system
BackgroundThe neurocircuits that process somatic sensory information in the dorsal horn of the spinal cord are still poorly understood, with one...
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TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch
Itch, the unpleasant sensation that evokes a desire to scratch, accompanies numerous skin and nervous system disorders. In many cases, pathological...
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Initiation of segmental locomotor-like activities by stimulation of ventrolateral funiculus in the neonatal rat
Descending control is critically important for the generation of locomotor activities. Yet, our understanding of the descending control system of...
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Therapeutic effects of recombinant Salmonella typhimurium harboring CCL22 miRNA on atopic dermatitis-like skin in mice
Th-2-biased immune responses are known to play a key role in the pathogenesis of atopic dermatitis. In particular, the macrophage-derived chemokine...
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Central mediation and differential blockade by cannabinergics of the discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats
RationaleDiscovery of an endocannabinoid signaling system launched the development of the blocker rimonabant, a cannabinoid CB1 receptor (CB 1 R)...
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Insights into the life and work of Sir Charles Sherrington
Much of the original historical data behind the greatest discoveries in neuroscience are now lost. However, a recently rediscovered box of...
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Kappa-Opioid Antagonists as Pruritogenic Agents
Norbinaltorphimine (norBNI), the prototype kappa-opioid receptor antagonist, N-benzylnorBNI, and 5′-guanidinonaltrindole (GNTI) precipitate...
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Analysis of Grooming Behavior and Its Utility in Studying Animal Stress, Anxiety, and Depression
In rodents, grooming is a complex and ethologically rich behavior, sensitive to stress and various genetic and pharmacological manipulations, all of...
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Influence of adiposity on cooling efficiency in hyperthermic individuals
This study evaluated the effect of body adiposity on core cooling rates, as measured by decreases in rectal ( T re ), esophageal ( T ...
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A comparison of the effects of the CB1 receptor antagonist SR141716A, pre-feeding and changed palatability on the microstructure of ingestive behaviour
RationaleThe cannabinoid CB 1 receptor inverse agonist SR141716A (rimonabant) is known to cause hypophagia and this study uses microstructural data...
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Motor Systems
“The neuronal networks of the brain create behaviour by ordering the execution of different movements and movement complexes which allow the organism...
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The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats
RationaleA growing body of evidence suggests that cannabinoid CB1 receptor antagonists have potential therapeutic utility as appetite suppressants....
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Identification of c-Fos immunoreactive brainstem neurons activated during fictive mastication in the rabbit
In the present study we used the expression of the c-Fos-like protein as a “functional marker” to map populations of brainstem neurons involved in...
