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Overweight and prognosis in triple-negative breast cancer patients: a systematic review and meta-analysis
We conducted a systematic review and meta-analysis investigating the association between overweight and outcome in triple-negative breast cancer...
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Comparison of different transient gene expression systems for the production of a new humanized anti-HER2 monoclonal antibody (Hersintuzumab)
BackgroundProducing therapeutic proteins can be done quickly and on a large scale through Transient Gene Expression (TGE). Chinese hamster ovary...
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Survival outcomes in endometrial cancer patients according to diabetes: a systematic review and meta-analysis
BackgroundDiabetes is an established risk factor for endometrial cancer development but its impact on prognosis is unclear and epidemiological...
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Clinical profile of COVID-19 infection among persons with spinal cord injury: a case series
Study designRetrospective case series.
ObjectiveTo report the clinical features and outcomes of spinal cord injury (SCI) patients with COVID-19 and...
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Screening of Obstructive Sleep Apnea (OSA) Risk and Study of Its Predictors in a Population of Adult Indians
PurposeThe current study is the first attempt to screen obstructive sleep apnea (OSA) risk in adult populations of Chhattisgarh, India. A few...
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Investigator choice of standard therapy versus sequential novel therapy arms in the treatment of relapsed follicular lymphoma (REFRACT): study protocol for a multi-centre, open-label, randomised, phase II platform trial
BackgroundRelapsed or refractory follicular lymphoma (rrFL) is an incurable disease associated with shorter remissions and survival after each line...
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Real-world patient-reported outcomes and physician satisfaction with poly (ADP-ribose) polymerase inhibitors versus chemotherapy in patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2–negative advanced breast cancer from the United States, Europe, and Israel
BackgroundIn clinical trials, poly (ADP-ribose) polymerase inhibitors (PARPi) versus chemotherapy resulted in significantly improved progression-free...
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Complex spiking neural networks with synaptic time-delay based on anti-interference function
The research on a brain-like model with bio-interpretability is conductive to promoting its information processing ability in the field of artificial...
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Process Modelling, Scale-Up and Characterization of Acetaminophen Spray Dried Milk Powder as Novel Pediatric Dosage Form
PurposeSuccessful drug therapy in children is contingent upon hassle-free administration of pediatric dosage forms. Pediatric patients suffer from...
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Therapeutic angiogenesis for patients with no-option critical limb ischemia by adipose-derived regenerative cells: TACT-ADRC multicenter trial
BackgroundPatients with critical limb ischemia (CLI) still have a high rate of lower limb amputation, which is associated with not only a decrease in...
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Dispersion profile of a needle-free jet injection depends on the interfacial property of the medium
Injections into or through the skin are common drug or vaccine administration routes, which can be achieved with conventional needles, microneedles,...
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Lympho-vascular invasion impacts the prognosis in breast-conserving surgery: a systematic review and meta-analysis
BackgroundIt is estimated that breast cancer (BC) incidence, especially that of early-stage breast cancer cases continues to rise due to increased...
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Why does circadian timing of administration matter for immune checkpoint inhibitors’ efficacy?
BackgroundTolerability and antitumour efficacy of chemotherapy and radiation therapy can vary largely according to their time of administration along...
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Whole-Blood Metabolomics of a Rat Model of Repetitive Concussion
Mild traumatic brain injury (mTBI) and repetitive mTBI (RmTBI) are silent epidemics, and so far, there is no objective diagnosis. The severity of the...
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Evaluation of dynamic recurrence risk for locally advanced gastric cancer in the clinical setting of adjuvant chemotherapy: a real-world study with IPTW-based conditional recurrence analysis
BackgroundThe long-term dynamic recurrence hazard of locally advanced gastric cancer (LAGC) in the clinical setting of adjuvant chemotherapy (ACT)...
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Interaction analysis of high-risk pathological features on adjuvant chemotherapy survival benefit in stage II colon cancer patients: a multi-center, retrospective study
BackgroundWe aimed to analyze the benefit of adjuvant chemotherapy in high-risk stage II colon cancer patients and the impact of high-risk factors on...
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Neoadjuvant radiotherapy for resectable retroperitoneal sarcoma: a meta-analysis
BackgroundNeoadjuvant radiotherapy (NRT) for resectable retroperitoneal sarcoma (RPS) has been shown to be systematically feasible. Whether NRT has...
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Baseline Albumin-Bilirubin grade as a predictor of response and outcome of regorafenib therapy in patients with hepatocellular carcinoma: a systematic review and meta-analysis
BackgroundThe use of regorafenib in the treatment of hepatocellular carcinoma (HCC) is widespread. Albumin-Bilirubin (ALBI) has been shown to be a...
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Prognostic impact of tumor length in esophageal Cancer: a systematic review and Meta-analysis
BackgroundIn clinical studies, it has been observed that esophageal cancer (EC) patient prognosis can be very different even for those patients with...
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Feasibility and safety of EGFR-TKI neoadjuvant therapy for EGFR-mutated NSCLC: A meta-analysis
BackgroundThe role of neoadjuvant epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) targeted therapy for EGFR-mutated non-small...
