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Preparation of NanoMEDIC Extracellular Vesicles to Deliver CRISPR-Cas9 Ribonucleoproteins for Genomic Exon Skip**
The CRISPR-Cas9 system has quickly become the standard tool for genome editing. To deliver this system to target cells, adeno-associated virus (AAV)...
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Radionuclide Reporter Imaging to Visualize Tumor Hypoxia Ex Vivo and In Vivo
In vitro studies using cell culture, including three-dimensional cultures without the involvement of tumor vessels, have limitations in simulating...
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Effective protection of photoreceptors using an inflammation-responsive hydrogel to attenuate outer retinal degeneration
Retinitis pigmentosa (RP) is an outer retinal degenerative disease that can lead to photoreceptor cell death and profound vision loss. Although...
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Long Non-coding RNA ANRIL and Its Role in the Development of Age-Related Diseases
ANRIL is known as a lncRNA that has many linear and circular isoforms and its polymorphisms are observed to be associated with the pathogenesis of...
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Revisiting JC virus and progressive multifocal leukoencephalopathy
Since its definition 65 years ago, progressive multifocal leukoencephalopathy (PML) has continued to devastate a growing population of...
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Vaccines, Vaccination, and Immunization
Vaccines are based on antigens from pathogenic microbes or the toxins they produce that induce adaptive immune responses for protection from...
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Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis
The capacity to survive and thrive in conditions of limited resources and high inflammation is a major driver of tumor malignancy. Here we identified...
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Evaluation of the virucidal efficacy of disinfectant wipes with a test method simulating practical conditions
BackgroundThe use of disinfectant wipes in hospitals is increasing over the last years. These wipes should be able to inactivate microorganisms...
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Miscellaneous Viruses
Miscellaneous viruses described in this chapter include a diverse group of viruses that have been increasingly associated with infections in humans....
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AAV-vectored expression of monospecific or bispecific monoclonal antibodies protects mice from lethal Pseudomonas aeruginosa pneumonia
Pseudomonas aeruginosa poses a significant threat to immunocompromised individuals and those with cystic fibrosis. Treatment relies on antibiotics,...
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Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation
The lack of a scalable and robust source of well-differentiated human atrial myocytes constrains the development of in vitro models of atrial...
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Available Preclinical Tools for Neuroblastoma
Neuroblastoma is the most predominant and deadly cancer in infants and in young children and contributes significantly to childhood cancer deaths....
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The interactions between PML nuclear bodies and small and medium size DNA viruses
Promyelocytic leukemia nuclear bodies (PM NBs), often referred to as membraneless organelles, are dynamic macromolecular protein complexes composed...
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CK2-mediated phosphorylation of Che-1/AATF is required for its pro-proliferative activity
BackgroundChe-1/AATF (Che-1) is an RNA polymerase II binding protein involved in several cellular processes, including proliferation, apoptosis and...
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Mfap4: a promising target for enhanced liver regeneration and chronic liver disease treatment
The liver has a remarkable regenerative capacity. Nevertheless, under chronic liver-damaging conditions, this capacity becomes exhausted, allowing...
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BCL2 inhibition stimulates dendritic cell function for improved anticancer immunotherapy
Recently we developed a dendritic cell (DC) genotype-phenotype screening platform that is based on CRISPR/Cas9-mediated gene editing of immortalized...
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Assays Based on Pseudotyped Viruses
Pseudotyped viruses are more and more widely used in virus research and the evaluation of antiviral products because of their high safety, simple...
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Mutant K-Ras-Mediated Oxidative Stress in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is one of the highly lethal cancers with dismal prognosis due to lack of effective targeted therapies and...
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Mice as Experimental Models for Cancer Research
Cancer is a devastating disease affecting a large number of people worldwide. There has been relentless effort to learn various aspects of the...
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Connexin 43 regulates astrocyte dysfunction and cognitive deficits in early life stress-treated mice
Early life stress such as maternal separation (MS), is a major risk factor for develo** psychiatric disorders in adulthood. Connexin 43 (CX43), the...
