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Facilitation of dependent transfers with functional neuromuscular stimulation: a computer simulation study
A two-part simulation process was developed to investigate the facilitation of vertical patient lifts with functional neuromuscular stimulation (FNS)...
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Repurposing metformin as a potential anticancer agent using in silico technique
BackgroundThe focus on repurposing readily available, well-known drugs for new, creative uses has grown recently. One such medication is metformin, a...
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European evidence-based recommendations for clinical assessment of upper limb in neurorehabilitation (CAULIN): data synthesis from systematic reviews, clinical practice guidelines and expert consensus
BackgroundTechnology-supported rehabilitation can help alleviate the increasing need for cost-effective rehabilitation of neurological conditions,...
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Exploring the Neural Underpinnings of an Antidepressant and Rewarding Action of Early Anorexia
Organisms do not make the decision to feel hungry, but they can decide to satisfy, or to not satisfy, hunger. Consuming foods then maintains energy...
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Interferons and Interleukins
In this chapter, the complex role of interferons and interleukins in our defense system to defend against, contain, or eliminate toxic or invasive...
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Current Treatments for Malaria
Antimalarial drug therapy is the recommended measure for malaria patients. In the chapter, the treatment for uncomplicated malaria, severe and...
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Oxidative Stress in Men with Obesity, Metabolic Syndrome and Type 2 Diabetes Mellitus: Mechanisms and Management of Reproductive Dysfunction
Reactive oxygen species (ROS) are critical physiological mediators of cellular function, including male fertility. When ROS exceed antioxidant...
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Combination effect of three anti-HSV-2 active plant extracts exhibiting different modes of action
The emergence of multidrug-resistant viruses leads to discover a novel source of drugs or a new strategy to overcome this obstacle. Combined herbal...
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PARP inhibition with rucaparib alone followed by combination with atezolizumab: Phase Ib COUPLET clinical study in advanced gynaecological and triple-negative breast cancers
BackgroundCombining PARP inhibitors (PARPis) with immune checkpoint inhibitors may improve clinical outcomes in selected cancers. We evaluated...
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The role of anti-diabetic drugs in NAFLD. Have we found the Holy Grail? A narrative review
PurposeNon-alcoholic fatty liver disease (NAFLD) has become a leading cause of liver disease, affecting 30% of the global population. NAFLD...
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Mode of action-based risk assessment of genotoxic carcinogens
The risk assessment of chemical carcinogens is one major task in toxicology. Even though exposure has been mitigated effectively during the last...
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Pharmacological Profile of FDA-Approved Orphan Drugs in the Year 2022
Purpose of ReviewThis manuscript aimed to provide a scientific report of recently FDA-approved orphan drugs for hel** patients, researchers,...
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Constipation, Diarrhea, and Intestinal Obstruction in Palliative Care
The symptoms of bowel function, including constipation, diarrhea, and bowel obstructions, are problems that commonly affect palliative care patients....
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Classification of sEMG Signal-Based Arm Action Using Convolutional Neural Network
Prosthetic arms are rapidly gaining pace because of their use in the development of robotic prosthesis. The surface electromyography (sEMG) signal...
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Preliminary study of the mechanism of action of ethanamizuril against Eimeria tenella
Ethanamizuril (EZL) is a novel triazine compound with excellent anticoccidial activity. We carried out a preliminary investigation of the effects of...
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A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer
BackgroundThis was a first-in-human Phase 1/2 open-label dose-escalation study of the novel checkpoint kinase 1 (Chk1) inhibitor SRA737.
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Clinical pharmacogenomics in action: design, assessment and implementation of a novel pharmacogenetic panel supporting drug selection for diseases of the central nervous system (CNS)
BackgroundPharmacogenomics describes the link between gene variations (polymorphisms) and drug responses. In view of the implementation of precision...
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Development of a decision support tool to prevent community acquired pressure injuries for use in the spinal cord injury clinic using the delphi technique
Study designDelphi Technique.
ObjectivesDescribe the development of a decision support tool to prevent community-acquired pressure injuries (CAPrIs)...
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VECTRON™ T500, a new broflanilide insecticide for indoor residual spraying, provides prolonged control of pyrethroid-resistant malaria vectors
BackgroundBroflanilide is a newly discovered insecticide with a novel mode of action targeting insect γ-aminobutyric acid receptors. The efficacy of...
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Interpreting Imaging for Pre-Operative Planning and Execution of Glioma Surgery
Glioblastomas are infiltrative brain tumors with poor prognoses despite multimodal treatment, and maximum safe resection is recommended whenever...