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Remote detection of Cannabis-related impairments in performance?
RationaleResearchers have traditionally studied the effects of psychoactive drugs such as Cannabis in controlled laboratory settings or relied on...
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Antihistamine effects and safety of fexofenadine: a systematic review and Meta-analysis of randomized controlled trials
BackgroundAs a new generation antihistamine, fexofenadine has been widely used in allergic diseases. However, there is still a lack of collective...
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Total sleep deprivation impairs visual selective attention and triggers a compensatory effect: evidence from event-related potentials
Many studies have demonstrated the impairment of sustained attention due to total sleep deprivation (TSD). However, it remains unclear whether and...
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Insomnia-related rodent models in drug discovery
Despite the widespread prevalence and important medical impact of insomnia, effective agents with few side effects are lacking in clinics. This is...
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Psychometric methods for diagnosing and monitoring minimal hepatic encephalopathy —current validation level and practical use
Hepatic encephalopathy (HE) is cerebral dysfunction caused by liver failure and inflicts 30-40% of patients with liver cirrhosis during their disease...
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Robot-assisted minimally invasive thoraco-laparoscopic esophagectomy versus minimally invasive esophagectomy for resectable esophageal adenocarcinoma, a randomized controlled trial (ROBOT-2 trial)
BackgroundFor patients with esophageal adenocarcinoma or cancer of the gastroesophageal junction, radical esophagectomy with 2-field lymphadenectomy...
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Magnesium–ibogaine therapy in veterans with traumatic brain injuries
Traumatic brain injury (TBI) is a leading cause of disability. Sequelae can include functional impairments and psychiatric syndromes such as...
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Quetiapine improves sensorimotor gating deficit in a sleep deprivation-induced rat model
BackgroundSleep deprivation (SD) impairs pre-stimulus inhibition, but the effect of quetiapine (QET) remains largely unknown.
Objective ...
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Correlations between cerebrospinal fluid biomarkers, neurocognitive tests, and resting-state electroencephalography (rsEEG) in patients with HIV-associated neurocognitive disorders
HIV-associated neurocognitive disorders (HAND) are highly prevalent in people living with HIV (PLWH) despite successful treatment with combination...
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Connections Between Insomnia and Cognitive Aging
Insomnia is a common sleep disorder among older adults, and a risk factor for poor physical and mental health. However, the relationship between...
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Biopsychology of Chocolate Craving
Chocolate is the most desired food in the world, and it has always been considered as a pleasant food, sought after both for hedonistic reasons and...
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The effects of trazodone on human cognition: a systematic review
Trazodone is a widely used antidepressant that is also useful in the control of agitation and insomnia in Alzheimer's disease. This drug is now...
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Brain Damage in Sleep-Disordered Breathing: The Role of the Glia (clinical aspects)
Sleep-disordered breathing (SDB) occupies one of the leading positions in the structure of sleep disorders. SDB is accompanied by damage to brain...
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Photobiomodulation Improves the Inflammatory Response and Intracellular Signaling Proteins Linked to Vascular Function and Cell Survival in the Brain of Aged Rats
Photobiomodulation is a non-pharmacological tool widely used to reduce inflammation in many tissues. However, little is known about its effects on...
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Application of Cognitive Test Outcomes for Clinical Drug Development
Cognitive tests are objective measures of task performance providing insights into the potential of drug treatments to impact patient...
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Circadian Rhythm and Personalized Exercise
Almost all physiological and biochemical processes in the human body follow a circadian rhythm. Studies have found that the biological rhythms of the...
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A systematic review of physiological signals based driver drowsiness detection systems
Driving a vehicle is a complex, multidimensional, and potentially risky activity demanding full mobilization and utilization of physiological and...
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Augmenting hippocampal–prefrontal neuronal synchrony during sleep enhances memory consolidation in humans
Memory consolidation during sleep is thought to depend on the coordinated interplay between cortical slow waves, thalamocortical sleep spindles and...
