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Oncogenes, Signal Transduction and the Hallmarks of Cancer
In this chapter, we will understand that the observation that RNA tumor viruses can transform normal cells into cancer cells led to the discovery of...
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The role of m6A methylation in therapy resistance in cancer
Cancer therapy resistance is the main cause of cancer treatment failure. The mechanism of therapy resistance is a hot topic in epigenetics. As one of...
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Dual contribution of the mTOR pathway and of the metabolism of amino acids in prostate cancer
BackgroundProstate cancer is the leading cause of cancer in men, and its incidence increases with age. Among other risk factors, pre-existing...
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Characterization of protein arginine methyltransferase of TgPRMT5 in Toxoplasma gondii
BackgroundProtein arginine methylation is a prevalent post-translational modification. The protein arginine methyltransferase family (PRMT) is...
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Roles of protein post-translational modifications in glucose and lipid metabolism: mechanisms and perspectives
The metabolism of glucose and lipids is essential for energy production in the body, and dysregulation of the metabolic pathways of these molecules...
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Cellular metabolism regulates the differentiation and function of T-cell subsets
T cells are an important component of adaptive immunity and protect the host from infectious diseases and cancers. However, uncontrolled T cell...
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Arginine Methylation of β-Catenin Induced by PRMT2 Aggravates LPS-Induced Cognitive Dysfunction and Depression-Like Behaviors by Promoting Ferroptosis
Depression is a prevalent and debilitating psychiatric disorder, imposing substantial societal and individual burdens. This study aims to investigate...
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The Mutual Regulatory Role of Ferroptosis and Immunotherapy in Anti-tumor Therapy
Ferroptosis is a form of cell death that is triggered by the presence of ferrous ions and is characterized by lipid peroxidation induced by these...
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Cuproptosis-Related Gene FDX1 Suppresses the Growth and Progression of Colorectal Cancer by Retarding EMT Progress
Colorectal cancer (CRC) is a usual cancer and a kind of lethiferous cancer. Cuproptosis-related gene ferredoxin 1 (FDX1) has been discovered to act...
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Epigenetic Regulation of Cancer by Natural Touch: Phytochemicals and Epigenetic Regulation
Cancer is a substantially lethal cell disease characterized by uncontrolled cell proliferation and neoplastic progression resulting in dysfunction of...
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Histone methyltransferase and drug resistance in cancers
A number of novel anticancer drugs have been developed in recent years. However, the mortality of cancer patients remains high because of the...
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MicroRNAs overexpressed in Crohn’s disease and their interactions with mechanisms of epigenetic regulation explain novel aspects of Crohn’s disease pathogenesis
BackgroundIn this review, we were interested to identify the wide universe of enzymes associated with epigenetic modifications, whose gene expression...
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Epigenetic Mechanisms: DNA Methylation and Histone Protein Modification
Epigenetic Regulation Allows Control of Differential Gene Expression from the Same Genome. Every somatic cell in a given organism contains the same...
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Identification of key genes in chronic intermittent hypoxia-induced lung cancer progression based on transcriptome sequencing
BackgroundObstructive sleep apnea (OSA) is associated with increased risk of lung cancer mortality. Nevertheless, little is known about the...
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Patient-derived organoids in human cancer: a platform for fundamental research and precision medicine
Cancer is associated with a high degree of heterogeneity, encompassing both inter- and intra-tumor heterogeneity, along with considerable variability...
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Inducible Prmt1 ablation in adult vascular smooth muscle leads to contractile dysfunction and aortic dissection
Vascular smooth muscle cells (VSMCs) have remarkable plasticity in response to diverse environmental cues. Although these cells are versatile,...
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Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance
The methylation of arginine residues in proteins is a post-translational modification that contributes to a wide range of biological processes. Many...
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Regulation and targeting of SREBP-1 in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is an increasing burden on global public health and is associated with enhanced lipogenesis, fatty acid uptake, and...
