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Surgical implantation of human adipose derived stem cells attenuates experimentally induced hepatic fibrosis in rats
BackgroundMesenchymal stem cells (MSCs) are multipotent stromal cells and could exert hepatoprotective effects against acute liver injury,...
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Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification
Hepatic organoids are a recent innovation in in vitro modeling. Initial studies suggest that organoids better recapitulate the liver phenotype in...
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Molecular Pathways and Animal Models of Defects in Situs
Left–right patterning is among the least well understood of the three axes defining the body plan, and yet it is no less important, with left–right...
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Bipotent transitional liver progenitor cells contribute to liver regeneration
Following severe liver injury, when hepatocyte-mediated regeneration is impaired, biliary epithelial cells (BECs) can transdifferentiate into...
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Immune suppressive checkpoint interactions in the tumour microenvironment of primary liver cancers
Liver cancer is one of the most prevalent cancers, and the third most common cause of cancer-related mortality worldwide. The therapeutic options for...
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Genetic association and causal relationship between multiple modifiable risk factors and autoimmune liver disease: a two-sample mendelian randomization study
BackgroundThe intricate etiology of autoimmune liver disease (AILD) involves genetic, environmental, and other factors that yet to be completely...
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Hepatocellular Carcinoma and Human Gut Microbiome: Association with Disease and Scope for Therapeutic Intervention
Hepatocellular carcinoma (HCC) is the world’s third most prevalent cause of cancer-related mortality. HCC frequently occurs in patients with chronic...
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Coffee, adenosine, and the liver
A variety of observational studies have demonstrated that coffee, likely acting through caffeine, improves health outcomes in patients with chronic...
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Safety profile of autologous macrophage therapy for liver cirrhosis
Therapies to reduce liver fibrosis and stimulate organ regeneration are urgently needed. We conducted a first-in-human, phase 1 dose-escalation trial...
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Characterization of the intestinal fungal microbiome in patients with hepatocellular carcinoma
ObjectiveGut mycobiota plays a crucial role in benign liver diseases; however, its correlation with hepatocellular carcinoma (HCC) remains elusive....
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Clinical and imaging characteristics of primary hepatic sarcomatoid carcinoma and sarcoma: a comparative study
BackgroundPrimary hepatic sarcomatous carcinoma (PHSC) and primary hepatic sarcoma (PHS) are rare malignancies with frequent overlap in both the...
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Case report: progressive familial intrahepatic cholestasis type 3 with compound heterozygous ABCB4 variants diagnosed 15 years after liver transplantation
BackgroundProgressive familial intrahepatic cholestasis (PFIC) type 3 is an autosomal recessive disorder arising from mutations in the ATP-binding...
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Modified staging system of positive lymph nodes based nomogram in intrahepatic cholangiocarcinoma
BackgroundIntrahepatic cholangiocarcinoma (iCCA) presents the similar trend and prevalence of lymph node metastasis to other biliary tract cancer....
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Risk factors for antibiotic resistance and mortality in patients with bloodstream infection of Escherichia coli
This study aimed to investigate the risk factors for bloodstream infection (BSI) caused by extended-spectrum beta-lactamase (ESBL)–producing Escherichi...
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Liver Cancer
Liver cancer is a major lethal malignancy worldwide. This chapter describes the molecular pathogenesis of the main histological subtype,...
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Biallelic mutations of TTC12 and TTC21B were identified in Chinese patients with multisystem ciliopathy syndromes
BackgroundAbnormalities in cilia ultrastructure and function lead to a range of human phenotypes termed ciliopathies. Many tetratricopeptide repeat...
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How genetic risk contributes to autoimmune liver disease
Genome-wide association studies (GWAS) for autoimmune hepatitis (AIH) and GWAS/genome-wide meta-analyses (GWMA) for primary biliary cholangitis (PBC)...
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The gut-liver axis in hepatobiliary diseases
Recent advances in the analysis of intestinal bacteria have led to reports of variations in intestinal bacterial levels among hepatobiliary diseases....
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The crosstalk between cholangiocytes and hepatic stellate cells promotes the progression of epithelial-mesenchymal transition and periductal fibrosis during Clonorchis sinensis infection
BackgroundClonorchis sinensis infection is one of the risk factors that provokes chronic inflammation, epithelial hyperplasia, periductal fibrosis...
