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Antibacterial-Anti-Inflammatory-Bone Restoration Procedure Achieved by MIN-Loaded PLGA Microsphere for Efficient Treatment of Periodontitis
The main development process of periodontitis involves periodontal pathogenic bacteria as the initiating factor causing the onset of destructive...
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Role and Mechanism of BMP4 in Regenerative Medicine and Tissue Engineering
Bone morphogenetic protein 4 (BMP4) is emerging as a promising cytokine for regenerative medicine and tissue engineering. BMP4 has been shown to...
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Periostin: biology and function in cancer
Periostin (POSTN), a member of the matricellular protein family, is a secreted adhesion-related protein produced in the periosteum and periodontal...
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Gasdermin-d Played a Critical Role in the Cyclic Stretch–Induced Inflammatory Reaction in Human Periodontal Ligament Cells
It has been shown that cyclic stretch could induce inflammatory response such as pyroptosis and the release of IL-1β in human periodontal ligament...
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High-Throughput Combined Analysis of Saliva Microbiota and Metabolomic Profile in Chinese Periodontitis Patients: A Pilot Study
The onset and progression of periodontitis involves complicated interactions between the dysbiotic oral microbiota and disrupted host...
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Interleukin (IL)-35 Suppresses IL-6 and IL-8 Production in IL-17A-Stimulated Human Periodontal Ligament Cells
Interleukin (IL)-35 is a novel anti-inflammatory cytokine that is produced by regulatory T cells. IL-35 is reported to suppress IL-17A-producing...
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PI3Kγ controls IL-17A expression and attenuates alveolar bone loss in an experimental periodontitis model
ObjectiveIn this study, we investigated the modulatory effects of PI3Kγ on IL-17A expression and the progression of experimental periodontitis in...
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Cardiovascular Diseases and Periodontitis
Periodontitis is a chronic inflammatory disease of the tooth-supporting connective tissue and alveolar bone that is initiated by a bacterial biofilm...
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Cementum Proteins Beyond Cementum
Dental cementum is a specialized complex structural component of teeth, covering its roots. It is avascular, non-innervated, does not remodel but...
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Prefrontal cortex activity induced by periodontal afferent inputs downregulates occlusal force
The prefrontal cortex (PFC) plays an important role in several cognitive functions, such as planning, decision making, and social behavior. We...
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The biological behavior optimization of human periodontal ligament stem cells via preconditioning by the combined application of fibroblast growth factor-2 and A83-01 in in vitro culture expansion
BackgroundAs the optimal source of seed cells in periodontal tissue engineering, periodontal ligament stem cells (PDLSCs) have always been researched...
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Omega-3 Effects on Ligature-Induced Periodontitis in Rats with Fructose-Induced Metabolic Syndrome
Both periodontal disease (PD) and metabolic syndrome (MS) represent disorders of concern worldwide. Current evidence indicates that PD and MS might...
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Advances of exosomes in periodontitis treatment
Periodontitis is an inflammatory disease initiated by dysbiosis of the local microbial community. Periodontitis can result in destruction of...
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Circ_0085289 Alleviates the Progression of Periodontitis by Regulating let-7f-5p/SOCS6 Pathway
Periodontitis is a common chronic inflammation that often occurs in adults. Circular RNAs (circRNAs) play a vital role in inflammation-related...
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Functions of Periostin in Dental Tissues and Its Role in Periodontal Tissue Regeneration
The goal of periodontal regeneration therapy is to reliably restore teeth’s supporting periodontal tissue, while aiding the formation of new...
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Role of ascorbic acid in the regulation of epigenetic processes induced by Porphyromonas gingivalis in endothelial-committed oral stem cells
Periodontitis is a common inflammatory disease that affects the teeth-supporting tissue and causes bone and tooth loss. Moreover, in a worldwide...
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A New Luminescent Zn(II) Complex: Selective Sensing of Cr2O72− and Prevention Activity Against Orthodontic Root Absorption by Suppressing Inflammatory Response
A novel luminescent coordination polymer (CP) based on Zn(II) ions as nodes [Zn(OPY) 1.5 (Hbtc)] n ( 1 ), [H 3 btc = trimesic acid and...
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Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Ameliorates the Inflammatory Response in Periodontal Disease
Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a type I transmembrane protein that can modulate osteoblasts and bone mineralization....
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Applications of Nanotechnology in Dentistry
Dental oral tissue is facing significant changes in clinical treatments in dentistry. Different studies are present in the literature about the use...
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Preparation and Evaluation of IL-1ra-Loaded Dextran/PLGA Microspheres for Inhibiting Periodontal Inflammation In Vitro
Periodontitis is a chronic infectious disease, the course and progression of which are determined by the interaction between microorganisms and the...
