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Evaluation of AAV Capsids and Delivery Approaches for Hereditary Hemorrhagic Telangiectasia Gene Therapy
Nosebleeds and intracranial hemorrhage from brain arteriovenous malformations (bAVMs) are among the most devastating symptoms of patients with...
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CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery
IntroductionAcute stroke leads to the activation of myeloid cells. These cells express adhesion molecules and transmigrate to the brain, thereby...
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Functional and clinical roles of stromal PDGF receptors in tumor biology
PDGF receptors play pivotal roles in both developmental and physiological processes through the regulation of mesenchymal cells involved in paracrine...
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Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic paradigm of small vessel disease...
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Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity
BackgroundReduced folate carrier 1 (RFC1; SLC19a1) is the main responsible transporter for the B9 family of vitamins named folates, which are...
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Hyperglycemia with or without insulin resistance triggers different structural changes in brain microcirculation and perivascular matrix
Both type-1 and type-2 DM are related to an increased risk of cognitive impairment, neurovascular complications, and dementia. The primary triggers...
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Tunneling nanotubes evoke pericyte/endothelial communication during normal and tumoral angiogenesis
BackgroundNanotubular structures, denoted tunneling nanotubes (TNTs) have been described in recent times as involved in cell-to-cell communication...
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Upregulation of AQP4 Improves Blood–Brain Barrier Integrity and Perihematomal Edema Following Intracerebral Hemorrhage
In intracerebral hemorrhage (ICH), delayed secondary neural damages largely occur from perihematomal edema (PHE) resulting from the disruption of the...
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The protective effect of low-dose minocycline on brain microvascular ultrastructure in a rodent model of subarachnoid hemorrhage
The multifaceted nature of subarachnoid hemorrhage (SAH) pathogenesis is poorly understood. To date, no pharmacological agent has been found to be...
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Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice
Mild traumatic brain injury (mTBI) induced by low-intensity blast (LIB) is a serious health problem affecting military service members and veterans....
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Vascular PDGFR-alpha protects against BBB dysfunction after stroke in mice
Blood–brain barrier (BBB) dysfunction underlies the pathogenesis of many neurological diseases. Platelet-derived growth factor receptor-alpha...
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The CLDN5 gene at the blood-brain barrier in health and disease
The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and forms tight junctions which limit the passive diffusions of ions...
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Transgenic animal models to explore and modulate the blood brain and blood retinal barriers of the CNS
The unique environment of the brain and retina is tightly regulated by blood–brain barrier and the blood-retinal barrier, respectively, to ensure...
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Executive summary of the 14th HHT international scientific conference
Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder characterized by small, dilated clustered vessels...
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Navigating tumor angiogenesis: therapeutic perspectives and myeloid cell regulation mechanism
Sustained angiogenesis stands as a hallmark of cancer. The intricate vascular tumor microenvironment fuels cancer progression and metastasis, fosters...
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Sha** the brain vasculature in development and disease in the single-cell era
The CNS critically relies on the formation and proper function of its vasculature during development, adult homeostasis and disease. Angiogenesis —...
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Neuroinflammatory Biomarkers in Diabetic Encephalopathy: Linking Cholinergic and Cognitive Dysfunction
The progression of diabetes has been linked with disruption of the microvascular system, which may lead to other degenerative conditions, including...
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Propranolol or Beta-Blockers for Cerebral Cavernous Malformation: a Systematic Review and Meta-analysis of Literature in Both Preclinical and Clinical Studies
Cerebral cavernous malformation (CCM), either sporadic or familial, is a devastating vascular malformation affecting the central nervous system that...
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Inhibition of PFKFB3 in HER2-positive gastric cancer improves sensitivity to trastuzumab by inducing tumour vessel normalisation
BackgroundMultiple mechanisms have been proposed that lead to reduced effectiveness of trastuzumab in HER2-positive gastric cancer (GC), yet...
